↑ risk of diabetes in young women with non-alcoholic fatty liver disease

Diabetes is 4.6 times higher than non-alcoholic fatty liver disease
Big difference depending on gender and menopause… Considerations for the prevention and management of diabetes
Professor Seung-Ho Ryoo of Sungkyunkwan University and Yu-Soo Jang’s team published in the American Society for the Study of the Liver’s ‘Hepatology’

From left, Professor Ryu Seung-ho, Professor Jang Yoo-soo, and Researcher Kim Ye-jin

Non-alcoholic fatty liver, which promotes the development of type 2 diabetes, is the most dangerous in young pre-menopausal women, according to a new study.

Previous studies have known that non-alcoholic fatty liver disease is a major risk factor for type 2 diabetes.

A research team led by professors Seungho Ryu and Yoosoo Jang from Sungkyunkwan University School of Medicine (Kangbuk Hospital Data Management Center, Researcher Yejin Kim) analyzed 245,054 non-diabetic adults who underwent health examinations between 2011 and 2018, and males (130,286) in according to gender and menopausal status. , pre-menopausal women (109,810 people), and post-menopausal women (4958 people) were divided into three groups, and a comparative analysis according to the presence or absence of non-alcoholic fatty liver and follow-up for 5.3 years was carried out .

At follow-up, compared to the healthy group without NAFLD, the risk of developing diabetes was 4.6 times higher in premenopausal women, 2.7 times higher in postmenopausal women, and 2.2 times higher in men who showed the greatest increase in the relative risk of diabetes. These results were more pronounced as the severity of NAFLD increased.

Professor Ryu Seung-ho said, “Through this study, we have not only confirmed once again that NAFLD is an important predictor of diabetes, but also found that the relative effects of NAFLD vary greatly depending on gender and status the menopause.” “This suggests that the differential effects of non-alcoholic fatty liver disease by gender need to be considered in order to effectively prevent and manage diabetes,” he explained.

Professor Jang Yoo-soo said, “Recently, the incidence of non-alcoholic fatty liver disease is increasing rapidly in young adults due to the influence of Western eating habits and less physical activity. “Young women should also pay attention to manage lifestyle to prevent metabolic diseases, including non-alcoholic fatty liver,” he said.

The study was published in the Journal of the American Association for the Study of the Liver (AASLD). (OS: 17.298).

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