Department of Life Sciences Professor Jinhee Han’s team, First clarification of the principle of memory encoding in neurons with enhanced synaptic connections
Using optogenetic technology, Expected to discover clues to treat dementia by proving the principle of memory formation for the first time
KAISTA research team led by Professor Jinhee Han of the Department of Life Sciences has identified the fundamental principle that neurons encoding memories are selected from a complex neural network composed of countless neurons and synaptic connections between them. 13day said.
Past experiences are stored in the brain in the form of memories and retrieved later.. It is known that these memories are encoded and stored in a very small number of neurons throughout the brain.. But are these neurons predetermined?, Or it is uncertain by what principle it is selected. Solving this question is not only of great academic importance, but also of elucidating how memories are formed in the brain, which is one of the unsolved challenges of neuroscience., A huge society because it provides clues to treat dementia, have an economic ripple effect.
More than half a century ago, the Canadian neuropsychologist Donald Oldingheb(Donald O. Hebb)is his famous book ‘organization of behavior(The Organization of Behavior)’ (1949) synaptic plasticity that the synaptic connection between these two neurons will be strengthened if two neurons are activated simultaneously in time(synaptic plasticity) presented an idea, Then, through experimentation, learning actually strengthens organs at specific synapses.(long-term potentiation, Below LTP)has been shown to occur.
after this discovery, LTPhas been thought to be a key mechanism of memory. However, LTPSo far, it has not been elucidated how the brain determines the neurons that encode memories..
In this study, the mouse brain amygdala was(amygdala) in natural learning conditions in the region LTPThe research team investigated whether the neurons encoding memories were changed when artificially strong or weakly manipulated synapses that do not occur by stimulating them in a specific pattern using optogenetic technology..
first, It stimulates these synapses before the mice experience the frightening experience. LTPwhen made to happen, Memory is encoded in this synapse, which was originally unrelated to memory. LTPfound that the neuron that occurred selectively participates in memory encoding with a very high probability compared to other neurons in the vicinity..
However, Immediately after learning, this synapse was artificially stimulated again with an optogenetic technique to weaken this synaptic connection, resulting in that memory is no longer encoded in this synapse and neuron..
Contrary, Normally, immediately after a mouse has had a frightening experience, LTP When this synaptic connection was artificially strengthened through stimulation, it was surprisingly LTPThe fear memory is encoded in this synapse that manipulated LTPconfirmed that it is selectively encoded in this neuron that generated. These results indicate that the memory itself does not change when synaptic strength is artificially manipulated., It was demonstrated that the neurons encoding those memories change..
Professor Jinhee Han “LTPA new connection pattern is created between neurons by the(cell assembly)are newly formed in the brain”said “It was discovered that the formation of these strongly interconnected neurons is the principle of memory formation in the brain.”He explained the importance of the results of this study..
KAIST Iree Jeong, a researcher at the Department of Life Sciences1 The study, in which I participated as an author, was published in Open Access by the Nature Publishing Group.(Open-access) academic journal ‘Nature Communications(Nature Communications)’on 6month 24posted on the day.
thesis name Synaptic plasticity-dependent competition rule influences memory formation to be.