[유전자 건강학] Even DNA ages … Genes associated with aging |

Aging is a biological phenomenon that appears to be universal. However, it is difficult to define properly. Basically, aging starts after sexual maturity. decline in body function with ageingit can be said It is called the biological ‘signature’ of ageing Changes that occur at the molecular and cellular level reduce the so-called homeostasis with which cells can maintain themselvesis to do

A decrease in the function of each cell eventually causes disease. Aging is a major cause of many chronic diseases later in life, including Alzheimer’s disease, chronic kidney disease, coronary artery disease, osteoarthritis, stroke and type 2 therefore Slowing down aging prevents many of these diseasesable to do

Aging is natural Another issue is how old you arein. When does aging start? Is aging a disease? can i have it back can you slow it down? It’s a tricky question that even scientists who study aging can’t answer with certainty.

However, as human life expectancy increases, interest in living a long and healthy life increases. I’m aging with my peers, but why do I seem to age faster? How can we explain the different rates of aging when we live in a similar environment to our friends?

Over the past 100 years, human life expectancy has increased rapidly. Celebrating 100 years For healthy ageing, it is necessary to understand the basic mechanisms of ageing. targeting large populations By studying the relationship between aging and genes through genome analysis, it is possible to discover genes associated with biological characteristics that occur during aging, including human lifespan. gene traits, to be precise. The rate of aging varies according to the difference in genotypeIt is. Aging faster than your genetically predisposed friends means you are more likely to develop chronic diseases.

Is aging hereditary? As a result of large-scale genomic studies, it was possible to find genetic variations related to longevity. However, when comparing individuals in the highest and lowest deciles with high aging genotypes, there was only a small difference in life expectancy of 3 to 5 years. Instead, there are APOE (Apolipoprotein E) and LPA (Lipoprotein A) genes. Genes associated with aging have a high correlation with the prevalence of chronic diseases. Rather than genes themselves determining lifespan, chronic diseases can occur more easily with age.

especially Incidence of chronic diseases is linked to parental life expectancydo. According to the results of data analysis of 500,000 people from the UK BioBank, the longer the parents lived, the lower the possibility of coronary artery disease or cancer. Roughly speaking, if your parents lived 10 years longer, your chance of developing a chronic disease was reduced by around 20%.

Human lifetime heritability is as low as 10%. So how do we explain the different rates of aging for each person? get old Continuous exposure to UV rays and active oxygen causes changes in DNA. during DNA changes When chromosome ends are shortened or mutated, cells are damaged or function is reduced.

There is also a chemical degradation that causes DNA methylation. especially DNA methylation increases proportionally with age to the extent that it is used as an indicator of DNA methylation can be different even at the same agein. Even in the case of identical twins, there is no difference between them when they are young, but the difference gradually increases as they get older. Such Differences in naturally occurring DNA changes cause different rates of agingin. Representatively DNA methylation pattern analysis can reveal the chronological age and other biological ages.

Mitochondria play a major role in maintaining cell homeostasis under various stressful situations. The function of mitochondria, the power plant that supplies energy in cells, is A definite effect on cell agingcrazy especially mitochondrial The amount of NAD+ (Nicotinamide adenine dinucleotide), a key metabolite, gradually decreases during the aging It is also expected to have an anti-aging effect that supports mitochondrial functions by supplying NAD+, which decreases.

according to aging The decrease in the amount of NAD+ is accelerated by mutations in mitochondrial In particular, mitochondrial DNA is easily mutated. This is because the DNA repair system is inefficient and active oxygen is produced inside the mitochondria.

It is difficult to calculate my age by DNA analysis. but Aging is a major factor in chronic disease, so it is important to calculate the age of your inherent Repeated monitoring of DNA methylation or mitochondrial mutations can show how much DNA is aging. of course It is more important to avoid stress, alcohol and smoking so that DNA does not agedo.


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