A mysterious study helps solve how sleep protects against heart disease

News Release

Wednesday, February 13, 2019

Researchers say they are closer to solve the mysterious way of sleeping a good night sleep against heart disease. In studies using mice, they found a mechanism between the brain, bone spine, and protecting the blood vessels protecting against the development of atherosclerosis, or the hardening of the arteries – except when sleep is healthy and sound. The study, funded by the National Heart, Lung, and Blood Institute (NHLBI), part of the National Health Institutions, will be featured in the magazine Nature.

This way sets out the importance of high quality sleeping to maintain cardiovascular health and can provide new targets for combating heart disease, the cause of the death of women and men in the United States, said researchers.

"We have acknowledged a mechanism by which a brain hormone produces inflammatory cells in the smeara in a way that helps protect the blood vessels from behind," explains Filip Swirski, Ph.D., the principal author of the study as well Associate professor at Harvard Medical School and Massachusetts General Hospital, Boston. "This anti-inflammatory mechanism is regulated by sleeping, and it breaks down when you often sleep or if there is poor sleep quality. It's a little bit of a bigger answer."

Swirski noted that while there may be other similar mechanisms, however, the results are exciting. There is a lack of sleeping and certain sleep disorders, such as sleep apnea, with increased risk of obesity, diabetes, cancer and heart disease to recent research. But scientists know a little about cellular and molecular feeds that can help explain the link between sleep and cardiovascular health.

It is a major public health problem that is sleepless or insufficient that affects millions of people of all ages. Studies show that many quality sleep at times are crucial to health, but fewer than half adults in the United States receive the recommended seven-eight hours a day.

To learn more about the impact of this deficiency on cardiovascular disease, researchers focused on genetically engineered mice group to develop atherosclerosis. They put on the sleeping patterns of half the mice and usually allowed the other half sleep.

Over time, the mice developed sleeping into the pursuit of art longer than the other mice. Specifically, a muse developed into the sleep of artistic treatments or fatty deposits, which were up to a third more than the mice with normal sleep patterns. In addition, double sleeping mice at the level of certain inflammatory cells are produced in their circulatory system than the control mice – and lower amounts of hypocretin, a brain-made hormone that is considered to have a central role in sleeping and sleeping say.

The researchers also indicated that less atherosclerotic symptoms were found to have had hypocretin supplement with less inflammatory cells to develop lesser atherosclerotic atoms compared to mice that did not get the supplement. These results, which they said, show that the loss of hypocretin during sleeping inflammation and atherosclerosis. But they warned that more studies, especially in the case of humans, need to be validated and especially before therapeutic hypocretin was tested.

However, health experts say that focusing on new treatments for heart disease, sleeping and other disorders can be focused on the newly discovered biological mechanism – so-called neuro-immune back.

"This seems to be the most direct demonstration of the molecular links that link cardiovascular risk factors and cardiovascular risk to sleeping health," said Michael Twery, Ph.D., director of the NHLBI National Center for Sleep Disorders Research. Circadian biology refers to the 24 hour internal body that regulates many genes in most tissues and regulates sleep cycles and wakes up.

"Understanding the impact of sleeping and circulatory health on cellular formulation and vascular disease opens new ways to develop improved treatments," said Twery.

This work was partially supported by NHLBI R35 HL135752, R01 HL128264, P01 HL131478, and the NIH R35 HL139598 grant. Additional institutions supported the study outside the NIH, including the American Heart Society. For a fuller funding exposure, see the full research section.

Editor's Note: February is the American Heart of February. During this month, NHLBI is launching #OurHearts, a national initiative to encourage everyone to take healthy heart behavior.

This press release describes a basic research decision. Basic research will increase our understanding of human behaviors and biology, which is the basis of promoting new and better ways of preventing, diagnosing and treating disease. Science is an implied and incremental process – every research takes precedence of previous discoveries, often in unexpected ways. The most advanced clinical progress without knowledge of basic research was possible.

Regarding the National Heart, Lung and Blood Institute (NHLBI): The NHLBI is the world leader in researching and supporting in the heart, lung, and blood diseases and sleep disorders that promote scientific knowledge, it promotes public health and saves life. For more information, go to www.nhlbi.nih.gov.

About the National Health Institutions (NIH):
NIH, a national medical research agency, comprises 27 Institutions and Centers and is part of the United States Department of Human Health and Human Services. NIH is the primary federal agency that carries out basic medical, clinical and transient medical research, and provides the causes, treatments and treatments for both common and uncommon diseases. For more information about NIH and its programs, go to www.nih.gov.

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Study

Sleeping seems to be hematopoiesis and it costs against atherosclerosis. DOI: 10.1038 / s41586-019-0948-2

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