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British researchers “Moderna booster shot after completion of Pfizer inoculation… 1000% increase in effect”



Medical staff are vaccinated at the Corona 19 Central Vaccination Center at the National Medical Center. [사진=연합뉴스]

[아시아경제 권서영 기자] Regarding the booster shot (additional vaccination) of the COVID-19 vaccine, a study result that ‘cross-inoculation’ significantly strengthens immunity drew attention.

The New York Times (NYT) reported on the 2nd (local time) that a research team at the University of Southampton in the UK measured the booster shot effect according to the type of vaccine in 2,788 people who had recently completed the second dose of the COVID-19 vaccine. Trial participants were selected for at least 70 days after receiving two doses of either AstraZeneca (AZ) or Pfizer vaccines.

The participants received booster shots with the primary and secondary vaccines and other vaccines each received. A total of seven vaccines were used in the test: AZ, Pfizer, Moderna, Janssen, Novavax, CureVac, and Balneva. Four weeks after the booster shot, the research team measured the participants’ Corona 19 antibody levels and explained, “The booster shot’s effectiveness in preventing COVID-19 infection reaches 90%. It is said that any kind of vaccine is effective.”

The researchers also explained that there was a difference in the effectiveness depending on the type of vaccine. Antibody levels increased by 30% compared to the control group when a booster dose of Balneva vaccine was given to those who received Pfizer vaccines in the 1st and 2nd doses, but increased by at least 1000% when the Moderna vaccine was boosted. The research team analyzed that “regardless of the type of vaccine used during the 1st or 2nd inoculation, when the mRNA-based vaccines Moderna and Pfizer were given booster shots, much more antibodies were produced than other vaccines.”


The cross-inoculation effect was also studied. According to the researchers, when the Pfizer vaccine was boosted in people who received the first and second doses of the AZ vaccine, antibody levels increased 25 times compared to the control group. This is higher than the 8-fold increase in antibodies when a person who received the Pfizer vaccine in the 1st and 2nd doses received a booster shot with the Pfizer vaccine. However, Dr. Saul Faust, who participated in the study, explained, “It is true that cross-vaccination with vaccines is effective, but most vaccines, regardless of the type, can prevent COVID-19 infection.”

Reporter Kwon Seo-young [email protected]

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