Discovery of a ‘causative gene’ for high prevalence of dementia in patients with heart disease

A Korean research team has discovered the causative gene for Alzheimer’s dementia, which has a high incidence in people with heart disease.

Gachon University Gil Hospital Gachon Medical Life Convergence Research Institute Professor Jo Seong-beom and KISTI Senior Researcher Hyo-jeong Baek announced on the 20th that they discovered the ‘ADIPOQ’ gene, which is the cause of the high incidence of Alzheimer’s disease in patients with heart disease , through extensive big data and experiments.

This study was conducted in collaboration with Gachon University of Medicine, KISTI, and the National Institute of Health.

Recently, various comorbidities (a state of having two chronic diseases at the same time, comorbidity) have been observed in patients with heart disease. In fact, the fact that the incidence of dementia in the heart disease group showing abnormal myocardial function is higher than that of the general public has been reported many times around the world.

Professor Cho said, “Through this study, we confirm that certain genes are involved in increased incidence of these two diseases.”

The research team confirmed through experiments that when the expression of the ‘ADIPOQ’ gene was suppressed in mouse heart cells, the expression of other cardiac dysfunction genes was changed. In addition, by analyzing data from 500,000 people provided by UK Biobank in the UK, it reconfirmed that the gene mutation ‘ADIPOQ’ is simultaneously associated with thickening of the heart muscles and cognitive dysfunction.

The results of this study were derived from an integrated analysis of domestic and US health and medical big data, gene analysis data, functional genome experiment data, and UK Biobank clinical and genomic big data.

Professor Cho said, “In the future, it will be possible to apply it to the development of diagnostic methods or drugs that can be applied to multiple diseases at the same time by discovering genes involved in multiple diseases.”

/Reporter Im Seung-jae isj@kyeongin.com

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