“Diuretics are not effective in preventing the recurrence of kidney stones”

delivery time2023-03-14 10:21

kidney stones

[출처: 서울아산병원]

(Seoul = Yonhap News) Reporter Han Seong-gan = A study has found that the diuretic hydrochlorothiazide does not help prevent the recurrence of calcium kidney stones.

To prevent the recurrence of calcium-containing kidney stones, thiazide diuretics are used to prevent the excretion of calcium in the urine.

HealthDay News reported on the 13th that the research team led by Professor Nasser Dayat, a nephrologist at the University of Bern, Switzerland, conducted a clinical trial on 416 patients with recurrent calcium-containing kidney stones.

The research team divided them into 4 groups, 12.5mg, 25mg, and 50mg of hydrochlorothiazide were given to 3 groups (102 people), respectively, and the other group was given a placebo as a control group for comparison.

After a mean follow-up of 2.9 years, the recurrence rate of kidney stones was 59% in the 12.5 mg hydrochlorothiazide group (n = 105), 56% in the 25 mg group (n = 108), and 49% in the 50 mg group (n = 101).

The placebo-treated control group (n=102) had a 59% recurrence rate of renal stones.

The research team explained that this result showed that the recurrence rate of kidney stones in the hydrochlorothiazide group was similar to that of the control group regardless of the dose given.

In addition, the hydrochlorothiazide group showed a higher number of side effects such as hypokalemia, gout, type 2 diabetes, skin allergy, and abnormal blood creatinine levels than the control group, the research team said.

The results of this clinical trial were published in the latest issue of the New England Journal of Medicine, an American medical journal.

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