Doctor Yong pointed out that hybrid vaccines may be able to cope with Omicron.
on November 30 Prof. Dr. Yong Phuworawan Head of the Center of Specialization in Clinical Virology, Department of Pediatrics Faculty of Medicine Chulalongkorn University Specifies that the use of a hybrid vaccine may be good for the mutant “Omicron” virus on its Facebook page. Yong Poovorawan To say that this virus has mutated 50 places and the sprite region has changed up to 30 places sounds shocking. In fact, genetic changes can occur at any time in the RNA group of important viruses. What does the changing position do? how important it is more than the number of changes
Prof. Dr. Yong said that This virus has a total genetics of nearly 30,000 nucleotides. A change of 50 or 100 per 30000 is possible because it’s been two years. 4,000 nucleotides and it’s about 1,270 amino acids, a change of 30 in 1270. If you say 30, it’s a lot. It can be normal. But more importantly depends on where you change the position.
“With the 30 changes in 1270, the structure of the sprite spikes retained its original shape. but causing more diversity Just like humans, we are still human, but our appearance, if modified, may change, become more handsome or ugly, there are possibilities. When viewed from the outside, it is still human. I still remember who has not changed until the shape is not the same can’t find it
“So when there is a change in the sprite spikes The immunity in this area may be reduced to some extent. Not completely cured. For example, if we have a high immunity we can prevent 90 percent of the new species may be reduced to 80 percent and if the immunity is lower. In the past, the Wuhan strains used to vaccinate were still able to protect against the Delta strains. Even with changes but requires a higher level of immunity.” Prof. Dr. Yong stated.
Prof. Dr. Yong also said that Likewise, the new species weakened the protective immunity. It may be necessary to have high immunity first. or if greatly reduced The vaccine itself has to change the species completely. A new strain of Omicron is required, pending study, protection in the immune system. Probably didn’t just use the immune system to sprite spikes. The whole virus contains different protein parts. Both structural and non-structural, up to 25 pieces. Sprite spines are only a portion that extends to attach to human cells. Vaccines aim to build immunity to hinder it. But in reality, the immune system may be needed to other parts of the virus, such as the envelope, the nucleocapsid, and others that we don’t know.
“Why is the immune system caused by infection? It will protect better than immunity caused by vaccines made from sprite only. Because they are immune to all viruses, not just sprite spikes. The infection builds up immunity. If combined with immunity from the vaccine will have a very high level of immunity. This is called hybrid immunity and can be better protected.
“Likewise, lethal vaccination simulates infection. Immune to both viruses including spikes And when combined with another sprite vaccine, it could be inferred why the immunity was so much higher. and likely to be immune to hybrid immunity
“In the future, it’s called hybrid immunity studies. should help to support Prevent virus mutation Because the immune system in the fight against viruses is not only sprite spikes. We have a wide variety of vaccines in our country. Hybrid vaccines may be good against mutant viruses.” Prof. Dr. Yong said.
