[NewsQuest = Gohebydd Gwyddoniaeth Kim Hyung-geun]The microbiome, which collectively refers to many E. coli in our intestines, contains tens of trillions of beneficial and non-beneficial microorganisms that play a major role in the health of people there.
More and more studies show that gut bacteria have potential benefits for our health.
A new study from the University of Washington School of Medicine shows that the gut microbiome has a significant impact on brain health, including Alzheimer’s.
Uncovering a correlation between gut microbiome and brain health
At the heart of the study is that people with Alzheimer’s disease (AD) have a different type of gut microbiome than healthy people.
Alzheimer’s disease is caused by the deposition of amyloid-β (Aβ) plaques caused by an increase in a protein called tau in the brain. However, changes in the microbiome play a major role here.
This protein is known to cause brain lesions as a key factor in the development of Alzheimer’s disease.
In experiments on mice, bacteria in the intestines of mice that were prone to cognitive impairment were transformed into other bacteria.
As a result, the team found that the altered gut bacteria changed the behavior of immune cells throughout the body, including nerve cells that promote brain damage associated with Alzheimer’s disease.
Dr said. David M. Holtzman, lead author of the study, “We gave the mice antibiotics for just one week, and we saw their gut microbiome status and their immune response. “We investigated whether a protein from’ the name tau and neurodegeneration, which is experienced. as we get older, related.”
“What’s interesting is that manipulating the gut microbiome can affect the brain without giving anything directly to the brain,” he explained.
Short chain fatty acids are compounds produced by certain types of gut bacteria. The research team identified three short-chain fatty acids associated with neurodegeneration in mice.
Dr. Linda McGavern, program director at the National Institute of Neurological Disorders and Stroke (NINDS), provided some funding for this study.
“This study could provide important insight into how the microbiome influences tau-mediated neurodegeneration,” he said. It can go crazy,” he suggested.
“If we manipulate the microbiome of mice that are genetically predisposed to neurodegenerative disease just before they start to show signs of the disease, we may be able to slow or stop neurodegeneration,” Holtzman said.
In other words, it is still cognitively normal, but observing the gut microbiome to prevent early Alzheimer’s disease can be a preliminary treatment.
The study was published in a recent issue of the scientific journal Science.
