Helicobacter pylori eradication treatment, coronary artery disease prevention effect

Seoul National University Bundang Hospital Department of Gastroenterology Professor Kim Na-young and his team research presentation

(From left) Seoul National University Bundang Hospital, Gastroenterology Department Professor Na-Young Kim, Specialist Kim Sang-Bin, and Cardiology Department Professor In-Chang Hwang

The heart beats about 100,000 times a day to supply blood to the body. In order to support the activity of the heart, the heart muscle itself also needs a lot of oxygen and nutrients. At this time, the three strands of blood vessels that carry blood to the heart muscle are called ‘coronary arteries’.

Coronary arteries are damaged by metabolic diseases such as hyperlipidemia, diabetes, and high blood pressure, and when arteriosclerosis, where cholesterol builds up on the walls of blood vessels, greatly narrows or blocks the inner diameter of blood vessels, it’ n cause serious heart

When most of the coronary arteries are blocked and the heart muscle dies, it is called a ‘myocardial infarction’, and when blood flow is blocked and chest pain is felt , it is called ‘angina pectoris’. Such Coronary artery disease is the second leading cause of death after cancer in Korea and the most common cause of death known as

In the midst of this, the team led by Professor Nayoung Kim from the Department of Gastroenterology at Seoul National University Bundang Hospital (expert Sangbin Kim in the Department of Gastroenterology, Professor Inchang Hwang in the Department of Cardiology) has developed a representative prevention and treatment method for gastrointestinal diseases such as gastric cancer and gastric ulcer. Helicobacter pylori eradication treatment reduces the risk of coronary artery diseasefound out that it does.

The research team has consistently noted the fact that Helicobacter pylori eradication treatment has a positive effect on improving diabetes and hyperlipidemia, which cause various vascular diseases. Specifically, in this study The effect of preventing cardiovascular disease in different age groups according to men and womenIt is worth noting that appearance

This study was conducted on 7,608 patients who underwent gastroscopy at Seoul National University Bundang Hospital between 2003 and 2022. The research team followed the cumulative incidence of coronary artery disease in 4,765 Helicobacter pylori-infected patients without coronary artery disease who had eradication treatment (n = 3783) and patients who did not eradicate (n = 982) for a long period of time. There were no differences between the two groups in terms of age, gender, alcohol consumption, smoking status, diabetes, hypertension, and aspirin intake, which allows an accurate comparison.

Propensity to be free of coronary artery disease after eradication treatment in men under 65 (left) and women under 65 (right), *The probability of being free of coronary artery disease in the Helicobacter eradication group (blue) is more significantly than in the rather high non-sterilizing (red) group
Propensity free of coronary artery disease after removing men under 65 (left) and women under 65 (right). The probability of not having coronary artery disease is higher in the Helicobacter pylori eradication group (blue) than in the non-eradication group (red).

results, The cumulative incidence of coronary artery disease was reduced in men and women who had Helicobacter pylori eradicated by eradication treatment compared to the non-eradication group.seemed to be especially The preventive effect was found to be greater in men under 65 and in women over 65.

Regarding these gender differences, the research team Since female hormones (estrogen) strengthen the immune response to infection and dilate blood vessels, the effect of preventing cardiovascular disease due to elimination treatment is estimated to be high in men under 65 or women over one year of age. 65 with relatively low levels of estrogen.doing

In this study, the research team proved that Helicobacter pylori eradication treatment had a positive effect on reducing the level of cholesterol and glycated hemoglobin (HbA1c), and indicated that it could significantly contribute to the prevention of severe cardiovascular disease caused by metabolic disease for the year it has a deep meaning

Professor Kim Na-young said, “Helicobacter pylori has recently been found to cause systemic inflammatory cytokine activation, lipid metabolism disorders, and vascular damage.” At the same time, since the inhibitory effect has been identified, active elimination needs to be considered. treatment if infection is confirmed.”

Meanwhile, the results of this study were published in the famous international journal ‘Helicobacter’.

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