How to Keep Viruses in our DNA Prisoners Disease

How to Keep Viruses in our DNA Prisoners Disease

Researchers say that environmental factors and diseases such as multiple sclerosis can cause retroviruses that are dormant in our genome.

Share on Pinterest
Scientists believe that we have dead retroviruses in our DNA left from our prehistoric ancestors. Getty Images

The human genomic is a verified graveyard of dead retroviruses, making up somewhere between 5 per cent and 8 per cent of our DNA, according to the most credible estimates.

These retroviruses are the majority of junk DNA in our bodies – basically, they are omitted from millions of years of evolution that has been deactivated and set aside.

Sort like the bin folder on your computer before you leave it.

Spooky, maybe, but was previously considered harmless. But many scientists are not so sure.

Recent research suggests that these human intellectual retroviruses, or HERVs, may increase a zombie, under the right conditions, that they would adversely affect our bodies.

They may be at the heart of conditions such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), and even schizophrenia.

Firstly, talk a little about what a retrovirus is there.

In the simplest terms, retrovirus works by putting its genom into a host cell DNA, so it is rather part of the cell's “code”.

In humans, the retrovirus is known to be the human immunodeficiency virus (HIV). This is why the common therapy for HIV antiretroviral drugs.

Most of the retroviruses are exogenous, which means they attack someone from outside the body and are transmitted through liquid, air, or other contact.

In contrast, the HERVs are intellectual, which means that they are already within us, coded into our DNA.

These are residues as our primordial ancestors were infected with retroviruses. Part of this code was left behind, and their harmful effects are ripped away.

“In evolution, retroviruses were genetic diversity vectors, jumping from species to species,” said Hervé Perron, PhD, one of HERV's research pioneers and founder of GeNeuro, a pharmaceutical company that develops HERV-specific treatments, with Healthline. “These retroviruses can first recreate the host gene, so that they can start genes and infect cells and re-transcribe their genetic information.”

This is against retroviral cells such as HIV, where infected cells have only inserted infected copies into DNA so that they are not transmitted exclusively.

In contrast, HERVs occur because these retroviral infections occurred in a significant number of cases in regions that would not affect the life of the newborn. And so they were still in our genome.

In some cases, researchers even speculate on these dead viruses some beneficial effects, including helping to formulate a prototype immune system as viruses were fighting with other viruses for the supremacy.

Any benefits aside, HERV is supposed to be dead. Retrovirus is a contagious agent alive, not a happy companion.

“Many of these HERVs helped to adopt a physiological function at the genomic, while others remain latent and dormant while retaining the potential of their viral origin,” explained Perron.

The problem for scientists is that when environmental factors and other factors affect these HERVs, they are waking up from their deep slumber.

“Environmental factors can be reactivated by environmental factors such as inflammation, mutations, drugs, or infection with other viruses,” said Dr. Patrick Küry, lead author of new paper on neural cell responses to HERVs in Frontiers in Genetics magazine.

In addition, “Even if they were coming from an intellectual copy, proteins is the final product of this word that could make viruses particles in some cases,” explained Perron.

These retroviral links may make the missing “environmental” link, making Küry the difference between a person who is developing MS or ALS or who stays healthy.

“MS is direct autoimmune attacks on myelin – fatty cover of nervous cells – in the brain and spinal cord, but we still don't understand how these attacks are drawn,” he wrote in a press release. “Subsequently, it was shown that RNA and protein HERV levels increase – the readings outs from HERV DNA reactivated – in the brain and spinal cord fluids, as well as their postnatal brain tissue.”

Essentially, the theory is that HERV proteins stimulate an immune reaction that damages myelin and can encourage MS, the researchers say.

If this theory emerges – and there are clinical studies, trials and therapies in the works – then we could develop more effective treatment for these degenerative diseases.

For example, if HERV protein neutralized antibodies work to help deal with these conditions, it would concretely illustrate the role these retroviruses play in these disorders and provide a route for new therapies.

A study published in March by researchers from the University of Basel in Switzerland contributed to this theory.

These researchers noted a “magnetic resonance imaging signal compatible with antibody rehabilitation potential that attacks HERV cover protein in dealing with progressive MS.

This may be important from repairing moelin which may be crucial to eradicating some of MS damage.

In addition, GeNeuro, Perron and his team are also auditing these HERV protein antibodies.

“Because of the burden of the HERV protein expressed in autopsies and the brain content we felt in patients, we realized that we should neutralize this protein first, so we bred and chose antibodies to neutralize the protein. This pathogenic effects, ”he said to Healthline.

The clinical trials of his staff are promising.

“When we continued the MRI analysis and studies we did, we saw after a year that there was a clear reduction of thalamus atrophy – that is the best indicator of MS disease progress – but the same in cortical atrophy. and the whole brain, ”he said.

After two years, 90 percent of participants wanted to continue and they were feeling better with the treatment, he said.

“We were strongly convinced that this effect was not transient and out of date,” he said.

.

Leave a comment

Send a Comment

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.