Identification of protein that regulates energy supply to ‘developmental nerve cells’

Home » Health » Identification of protein that regulates energy supply to ‘developmental nerve cells’

January 26, 2022
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Input: 2022-01-26 23:26:30

Reporter Song Hyeon-soo songh@busan.com

UNIST reveals mitochondrial regulation of ‘mtIF3’ protein with a fluorescent sensor

(From left) Researcher Soyeon Lee (first author), Professor Jaeik Kim, and Researcher Donggeun Park (first author). Provided by UNIST

[연구그림] The principle of a fluorescent sensor to visualize mitochondrial translation and the effect of regulating neuronal growth through the promotion of mitochondrial translation of mtIF3 protein. Provided by UNIST

<img decoding="async" src="https://i0.wp.com/www.busan.com/nas/wcms/wcms_data/photos/2022/01/26/2022012611292367546_l.jpg?w=800" alt="[연구그림] A photograph of the axon end under different conditions. Provided by UNIST" data-recalc-dims="1" /><span class="caption"><br /> [연구그림] A photograph of the axon end under different conditions. Provided by UNIST<br /> </span> </div> <p>It is a sensor that works on the principle that fluorescence is emitted when two substances necessary for mitochondrial translation meet. As translation is activated, the fluorescence intensity increases.</p> <p>As a result of the experiment, when mtIF3 protein was synthesized at the nerve cell terminal, the intensity of light detected by the fluorescent sensor increased.</p> <p>This is evidence that mtIF3 protein activates mitochondrial translation and aids in neuronal development, the team explained.</p> <p>An official from the research team said, “This study was able to discover the molecular mechanism that immediately regulates mitochondria at the nerve cell terminal. “This technique could be applied to various studies to find out whether it regulates</p> <p>The research results were published on the 7th in ‘BMC Biology’, a major academic journal in the field of life sciences.</p> <p>The research was carried out with the support of the National Research Foundation’s Leader Research, Mid-Range Research, and Basic Research Lab support projects and research support from the Seo Kyung-Bae Science Foundation.</p> 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Identification of protein that regulates energy supply to ‘developmental nerve cells’