Identifying the co-infection process of corona and influenza through 3D organoids |

Korea Centers for Disease Control and Prevention, National Institutes of Health, of stem cells do 3D human lung tissue(organoid)Corona uses19and taking the flu at the same time In this case, the researchers were able to identify the process of worsening lung damage. 25said the day.

The results of this study were published in an international journal Microorganisms and emerging infections(Emerging Microbes and Infections’ online version 5month 25It was published as a thesis on the date.

the title of the thesis ‘Reciprocal enhancement of SARS-CoV-2 and influenza virus replication in lung organoids derived from human pluripotent stem cells’in.

according to him corona19Patients with influenza and influenza have higher rates of severity and higher mortality. However, there were limitations to the study because there were limited in vivo models that could analyze the process..

To investigate the process, Kim Jung-hyeon of the National Institute of Health Research and Health Research Officer Choi Jang-hoon of stem cells 3D make human lung tissue.

3D Corona uses human lung tissue19If you get the flu and the flu, the virus together increases the receptors needed to enter the lung tissue, causing intracellular SARS coronavirus2(corona19 virus) sheep 10It was found that a doubling of.

As a result, the inflammatory response and organ damage increased, leading to a higher rate of morbidity and mortality. The mechanism of the increase has been identified.

National Institute for Health In the future, there will be new infectious diseases and For basic research on chronic diseases Active collaborative research between internal and external researchers I will supportHe said.


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