Implantation of “pig hearts” in humans about a pig that (not) a pig

The success of the 57-year-old man’s pig heart transplant took place at Maryland Hospital in Baltimore, where a team of Maryland Hospital cardiac surgeons performed a genetically modified pig heart transplant. with David Bennett, a terminally ill heart patient. that the medical team jointly diagnosed that A human heart cannot be implanted. Because health is too poor to enter the process He was bedridden for six weeks and had to be on life support before the operation.

If you have to risk “pig’s heart”, it’s the last option that may still have hope.

“I know there is no certainty to say whether the surgery will be successful or not. I only had two options: die or join this trial. I still want to live I knew it might be a mere dream, but it was the last option I had,” Bennett said, before undergoing the transplant.

The surgery took seven hours and Bennett became the world’s first human to receive a heart transplant from a genetically modified pig. It’s the first step in animal-to-human organ transplant trials.

A team of doctors from the University of Maryland Medical Center said that this organ replacement surgery confirms clear information. Genetically modified animal hearts It can work in the human body without immediate resistance. which one of the reasons is Genetically modified pigs have first eliminated several genes that the human body might resist.

Three days after the surgery, Bennett, who was normal, said: He hoped to get out of bed.

Bartley P Griffith, the surgeon who performed this surgery. said in the published document that This surgery was “Another step in tackling the organ shortage crisis” in the United States, where more than 100,000 people wait for organ donation, with 17 people waiting to receive organs donated each day.

Griffith said that Pig-to-human grafting is not a new idea. In the past, pig heart valves were widely used in humans. And the organs of pigs are just the right size to fit in a human.

Earlier, in October 2021, the US surgeon Successfully transplanting pig kidneys into humans The patients who received surgery were brain-dead patients. no chance to recover back to normal but still with life support

Likewise, the “kidneys” used to be implanted from pigs have been genetically engineered to stop the body from recognizing them as “kidneys”. “Foreign thing” and rejected by the body

The surgery was a success of the medical team of It took New York University Langone Health for two hours to connect a pig kidney to the blood vessels of a recipient of a brain-dead patient. to see if organs are functioning normally or if they are rejected when transplanted into humans

Dr. Robert Montgomery, lead researcher The starting point for this experiment came from the observation that pig kidneys function similarly to human kidney transplants. And it also seems to fit the body as well as the normal human kidney.

“It’s functioning normally and doesn’t appear to be rejected by the body,” said the lead researcher.

The surgeon also transplanted some of the pig’s thymus gland along with the kidney. They think the thymus may help stop the human body from rejecting pig kidneys over the long term. By acting to eliminate immune cells that may escape to fight the pig’s tissues.

Before coming to the success of this pig-to-human organ transplant. US scientist Successfully genetically engineered 37 pigs to free the virus hidden in their DNA. The results of these achievements were published in the journal Science in August 2017.

Starting with pig skin cells, 25 PERVs (porcine endogenous retrovirus) were found in pig DNA. The researchers then mixed pig cells with human cells and found that These viruses can escape and infect human tissue. So we use Crispr gene editing technology to get rid of those viruses. After that, using the same technology as cloning dollyma sheep, virus-free cells were cloned into the mother pig’s eggs. then create an embryo The results of the first pig genotype research resulted in 37 healthy genetically engineered piglets.



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