Incredible Virus Modification Findings Our Understanding of How They Spread

The IKEA furniture viruses of the world are alive. In the right cell type, a handful of instructions and some molecular tools can interfere with infected book card competitions.

No DIY builder wants to travel around town to collect materials – in theory, germs should not be different. But a new discovery suggests that at least one virus category can pull itself together even if its instructions are divided into separate cells.

A team of researchers from the Université de Montpellier in France recently conducted a group of viruses with a genome consisting of more than a separate section.

The assumptions they received were contrary to a number of underlying assumptions about how viruses reproduce.

To understand the truth of their discovery, we must first do the basics of renewing virus construction. A typical virus is a little more than a nucleic acid inside a protective container.

When smuggled within a living cell, this nucleic acid sequence is inserted into the host's genetic library or is used to combine the cell molecular assembly line to bring together new copies of the virus.

Almost all viruses incorporate their genetic blueprints to the length of one-or two-strand nucleic acids. But some single-stranded DNA viruses are described as 'multipartite'; This code is applied throughout the segments, each transmitted in a separate protein box.

It's like an IKEA manual to print on loose pages, and then you have to wait until an inept postal service delivers the full instructions. Certainly, some people may be very lucky to get the full set, but it is a good business model.

So it seems that multiplication viruses are running hard because of their own pages of genetic instructions delivered in this way. Which prompts questions about why such a reproduction method still exists.

But we can't really dismiss them – a variety of these stratified pathogens infect plants and fungi. Only a few years ago, one was acquired by animal infection first. They are barely obsolete.

"It is considered that the likelihood of a genome segment of a genome segment becoming essential during transmission is so high, its ability to successfully cause infection is a bad secret," says plant defender Anne Sicard.

Something in our understanding of how viruses must reproduce. The complete sets of instructions come into single cells after all, or there is something going on.

To dig deeper, use the team's necrotic baby stunt virus (FBNSV), pathogen peas and beans that are made up of eight viral chromos package.

Fluorescent probes were then used to locate the final delivery points of specific parts of the genom inside infected baby beans plants.

Using different colors of proofing and testing for combinations of separated partitions, the team was able to verify that it was highly likely that a total number of genetic segments would finish randomly within one cell. only.

But it does not seem to have prevented the copying of parts. This was true in the case of a segment that was not central to the most fundamental functions of the virus, such as replication, decomposition, and movement within the host.

“Overall, we have shown that individual host cells do not need to have separate parts of a virus genome, and that one genome segment accumulation in a cell is completely independent of the accumulation of others,” says virologist Stéphane Blanc.

The implications of the detection suggest that single series products may have wide impacts of genetic instructions, helping to activate segments in other cells.

The researchers found evidence for this hypothesis when they looked at the molecule encoded by the genome segment responsible for replication. Although less than half of the plant cells contained copies of this replica segment, its product was in almost 85 per cent of its cells.

Indirectly, this whole process is similar to the operation of multi-cellular organisms, and requires certain cells to take individual tasks to build an individual virus.

"This multicellular way of life can be adopted in numerous viral systems and a new research lease is opened up in virology," says Blanc.

This research was published in 2008 eLife.


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