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Insights into AstraZeneca, the COVID-19 vaccine that the Prime Minister will inject as the first dose – the standard

by news dir

In addition to the Sinovac vaccine from China, it will arrive in Thailand on February 24. There is also news that the AstraZeneca vaccine from Europe will arrive on the same day. If true, it is a surprise to the Ministry of Public Health to receive another vaccine to manage it further because the FDA has not yet approved the Sinovac vaccine for older people over 60 years.

If Prime Minister Gen Prayut Chan-o-cha wants to get the first vaccine to build confidence in the people, it should be this company. And is a vaccine that Thailand will be delivered from Siam Bioscience in the middle of the year So I have gathered details about the AstraZeneca vaccine to study in advance.

AstraZeneca Vaccine Timeline

AstraZeneca is a British-Swedish pharmaceutical company. Headquartered in Cambridge, England, it produces medicines for many diseases such as cancer, heart disease, kidney disease and respiratory disease. The COVID-19 vaccine, produced by the name AZD1222, was researched in collaboration with the University of Oxford. Viral Vector vaccine uses the chimpanzee adino virus (ChAdOx1) to carry the SARS-CoV-2 virus genetic material into the body.

In principle, this vaccine is safe. Because the carrier virus does not cause disease in people Viruses that cause COVID-19 Cut down to only the genetic material associated with the spike, which is used to stimulate the immune system.

Vaccine trial companyPhase 1/2 In April-May 2020, in 1,077 UK volunteers aged 18-55, no dangerous side effects were found. And can stimulate the immune system Later in May – August experimentPhase 2/3 In England (the same), there were three target groups: ages 18-55, 56-69, and over 70, 160, 160 and 240 people, respectively, experiencing the same side effects as the previous trial, such as pain at the injection site. Fever, muscle pain, headache. The elderly experienced less symptoms than adults. But the immunity is similar

partPhase 3 Additional trials were conducted in South Africa and Brazil, including 23,848 volunteers. (Follow up until November 2020) was published in the Lancet medical journal on Dec. 8, analyzed by 11,636 volunteers, found that those who received both normal doses were effective against infection with symptoms. 62.1% Those who received a low dose for the first time followed by a normal dose. It was found to be 90.0% effective, accounting for the total efficiency. 70.4% (Low dose was a result of wrong dose calculation in 2,741 volunteers but found to be more effective)

Severe side effects occurred in a total of 175 events, but 84 occurred in people who received the vaccine, but only 1 was vaccine-related.

Most recently, on February 1, researchers submitted a preprints in the Lancet medical journal about the results of the Phase 3 analysis, adding that after receiving the first dose, the results of the analysis of the first dose. The vaccine is effective 76% And when analyzing the mathematical models, it was found that the immune system was stable over 3 months, which if the second dose was 12 weeks away from the first dose (from at least 4 weeks), it would be effective. 82.4% Therefore, countries that do not have enough vaccines may postpone the second dose schedule.

Another advantage of the vaccine is that it can be stored at 2-4 ° C or in normal refrigerator. (Same as Sinovac vaccine). One vial contains 10 doses after opening and must be used within 6 hours, during which time can be placed at room temperature up to 30 ° C.

AstraZeneca vaccines are currently approved for emergency use in the European Union and 28 other countries such as Australia, India (it is the company’s production base, but it goes by the name Covishield), South Korea and Thailand (as of January 21, 2021). It is also certified. From the World Health Organization (WHO), also for emergency use.

Who can get the AstraZeneca vaccine?

The WHO Strategic Immunization Advisory Group (SAGE) recommendation of February 10, 2021 states that AstraZeneca can be administered to

  • People aged 18 years and over Means that the elderly can receive injections But the reason there is news that some European countries do not approve the injection. Since the sample group in Phase III had a small proportion of the elderly (age group 56-69 years 8% and 70 years and older 4%), considering the available evidence, WHO still recommends the injection in older subjects. 65 years and over
  • People with underlying disease Including obesity, heart disease, respiratory disease And diabetes Not considered a contraindication to vaccination. And should even get vaccinated Because it is a risk factor for severe symptoms As for other underlying diseases such as HIV virus disease Immune disease Always consult your doctor before getting any vaccine.
  • Pregnant women do not have an infant safety study. Therefore it is not recommended to inject whileLactating womenCan be vaccinated And do not have to stop feeding after vaccination This is because the vaccine does not contain viruses that are dividable as components.

Vaccine intolerance or severe anaphylaxis were not reported in past trials. However, the vaccine recipient should be observed 15 minutes after injection as with other vaccines. (For Thai, 30 minutes) and prepare medical preparation for emergency. If there is an allergic condition in the first injection The second dose should not be administered in conjunction with other vaccines. Spaced at least 2 weeks

AstraZeneca vaccine with Thailand

AstraZeneca vaccine has been in the Thai vaccine program since mid-November 2020, in both the 26 million pre-reserved doses and the international research and development basket. By supporting the budget for Siam BioScience company 600 million baht (at that time there was still a plan to join the COVAX project and the vaccine research and development basket in the country)

On October 12, 2020, a Letter of Intent was signed for the production and allocation of a research vaccine against COVID-19. Between the Ministry of Public Health Siam Bioscience, SCG and AstraZeneca at the Ministry of Public Health Before the signing ceremony for the COVID-19 vaccine By advance reservation and vaccine purchase contract that Gen. Prayut Chan-ocha presided over at the Government House on November 27, 2020

On January 12, 2021, the National Vaccine Institute posted clarification on why the COVID-19 vaccine from AstraZeneca could be delivered mid-year. This is because Siam Bioscience has received technology transfer. But five industrial vaccines are being produced.Each production cycle takes 118 days, allowing the vaccine to be delivered from the end of May to the beginning of June 2021.

Domestic AstraZeneca vaccine production process

(Reference: National Vaccine Institute page)

‘Valentine’s Day vaccination’ COVID-19 vaccination schedule The first Thai dose was on February 14, 2021. On 25 January, Anutin Charnvirakul, Minister of Public Health, interviewed that AstraZeneca’s vaccination was being prepared to enter the first lot. In February, 50,000 doses, but just one day later, the EU banned companies from exporting vaccines.

Until the afternoon of February 23, there was news that on February 24th, in addition to the Sinovac vaccine from China would arrive in Thailand, the AstraZeneca vaccine would also be given on the same day, totaling 4 hundred thousand doses, if true, it is counted as Surprise But, on the other hand, it reflected that early vaccine plans were highly uncertain. And may require a new vaccination plan to be adjusted again

Proofread: Pasinee Permphanphong

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