‘LAAB-Covid-19 vaccine’ in Thailand, effective but effective

On February 7, 2023, the National Vaccine Institute Organized an online academic discussion “According to Omicron and the use of the COVID-19 vaccine in Thailand” byDr Sopon Iamsirithaworn, Deputy Director General, Department of Disease Control He said the world has passed the COVID-19 pandemic. In Thailand, during 2020-2021, 2,223,435 cases of illness and 21,698 deaths.
In the year 2022, which is the period of the Omicron strain, there are 2,498,373 sick cases and 11,896 deaths, the death rate is relatively lower than the average. This is partly due to vaccines and other measures, and infection and death rates are at their lowest since the Omicron outbreak. The high morbidity rate is in the working age group. But the highest morbidity and mortality rate is in the age group of 70 years and over, which is 4%.

Case situation in 2023 last week The rate decreased in all groups, including 252 patients in hospitals, 122 pneumonia patients, 78 intubated patients, and 17 deaths. All deaths were in the elderly group. 8 people were not vaccinated at all, 1 person received a single dose, 3 people received a second dose, and 5 people received a booster dose for more than 3 months.

Vaccines save the lives of nearly 500,000 Thai people.
Vaccination coverage of Covid-19 As of February 6, 2023, there were more than 146 million doses of cumulative injections, the first dose covered 82.81%, the second dose covered 77.79%, the third dose covered 39.23%, the second dose covers 4 covers 9.44%, 5th dose covers 1.48% and 6th dose covers 0.09% Research confirms that 100 million doses of vaccination in Thailand prevent up to 490,000 deaths

“There are still around 2 million elderly people who have not been vaccinated at all, who are a risk group when they are infected with severe symptoms and are an age group at higher risk now. because other age groups have started to stop protecting themselves The closest to the Songkran festival, where it will go to the elderly So ask to be vaccinated in accordance with the recommendation of the Ministry of Public Health ” said Dr. Sophon.

And in 2023, it will also be a booster vaccination to prevent serious illness and death in all population groups. especially risk groups and it is between the Department and relevant agencies to discuss guidelines for an annual vaccine, as well as a flu vaccine which focuses on risk groups

4 doses of vaccine prevent 100% death

whileEmeritus Professor Dr Suwat Jariyalertsak Dean of the Faculty of Public Health Chiang Mai University Medical vaccination has been said to have four aims: to prevent infection, to reduce hospitalization, to reduce serious illness and to reduce mortality, the last two being the most important. During the Omicron epidemic, the study on the effectiveness and reduction of immunity from the COVID-19 vaccine, booster dose 3 and 4 during the outbreak of the Omicron virus was studied. using the Chiang Mai Province area database which has 2 research papers

First, a combination vaccine. Help reduce the chance of contracting COVID-19 During October-December 2021 (Delta period), it was found that

  • 2 doses of vaccine prevent infection by 63%
  • 3 needles prevent infection by more than 95%
    For the period February – April 2022 (Omicron range)
  • Two shots of the vaccine will not prevent infection.
  • 3 doses of vaccine prevent infection by 31%
  • and 4 doses of vaccine prevent infection by 75%

” Chiang Mai Province Area During the Delta outbreak, there were about 20,000 patients, 156 deaths, which is 0.78%, while during the Omicron outbreak, there were 300,000 cases of infection, 175 deaths, which is 0.06%, or reduction in deaths down 13 times. “Professor Emeritus Dr. Suwat

Probably because of 2 important reasons: 1. The severity of Omicron decreased. and 2. The population in Chiang Mai received more 3rd and 4th booster vaccines, so the booster vaccine in early 2022 is very important to reduce deaths and violence in Chiang Mai Province.

The effectiveness of the vaccine lasted 4 months.

and the second piece: a vaccine reduces the severity and death of COVID-19. during October-December 2021 (Delta period)

  • 2 doses of the vaccine reduce severity/death by 89%
  • 3 doses reduce severity / death by 100%
    For the period February – April 2022 (Omicron range)
  • 2 doses of the vaccine reduce severity/death by 80%
  • 3 doses reduce severity/death by 89%
  • and 4 doses reduce severity/death by 100%

In terms of effectiveness in reducing severity and death, how many months will it last? After receiving 3 or 4 stimulation needles, it was found that

  • For patients who received the 3-dose combination booster vaccine, the efficacy of the vaccine in reducing severity/death at 14-120 days after the last dose or 4 months was 91-93%.
  • If the time is more than 120 days, the effectiveness starts to decrease at 77%.
  • and if longer than 180 days or 6 months is reduced to 68%

“It is recommended that the population in the risk group of 608 receives 3 or 4 booster doses in 4 months or more after the last vaccination date. And from the comparative analysis of the effectiveness of the 3rd or 4th dose of the mixed formula vaccine COVID, whether AstraZeneca or mRNA, it was found that the effectiveness of reducing severity or death was not different. Therefore, they can choose any type of injection as they are voluntary,” said Professor Emeritus Dr Suwat.

'LAAB-Covid-19 vaccine' in Thailand, effective but effective

LAAB is still working in Thailand.

sideDr. Weerawat Manosutthi, Dr. Songwut, Department of Disease Control He said for the administration of long-acting antibodies: LAAB which is a long-acting antibody or immunotherapy Approved and registered in Thailand For prevention before exposure to pathogens, COVID-19 and treatment for COVID-19 through effective protection
From the results of the study, symptomatic prevention was found to be 82.8% after 6 months of follow-up and effectiveness of the treatment.
From the results of the study it was found that it can reduce the risk of serious disease Or death was 88% in the group received within 3 days after the onset of symptoms. And reduce the risk by 50% in the group admitted within 7 days of symptom onset.

“LAAB was able to respond to the omicron strain BA.2.75, which is the main endemic strain in Thailand. still retains the ability to prevent Omicron BA2.75 also compared to traditional species But other species found in foreign countries can reduce the effectiveness of prevention. Therefore, it is also beneficial to use, especially for vulnerable groups,” said Dr Wirawat.

Thailand has LAAB Serving about 2 hundred thousand doses, used by about 52,669 people and stocking 137,572 doses, with target groups for acceptance, including: 1. 607 risk groups, including the elderly and 7 group of chronic diseases who have not been vaccinated or received The last vaccine after 3 months

2. High risk groups with low immunity or who have been vaccinated but are unable to build up sufficient immunity, such as those who have had an organ transplant. Patients with end stage renal disease receiving renal replacement therapy, etc.

and 3. other cases at the discretion of the treating physician