New breed of covid Omicron, Doctor Yong opens 10 urgent questions that must be answered

News reports indicate that Prof. Dr. Yong Phuworawan (Mor Yong), head of the Center specializes in clinical virology. Department of Pediatrics Faculty of Medicine Chulalongkorn University Has posted on Facebook (Yong Poovorawan) with the message:
COVID-19, a new strain of Omicron (Omicron)
The world is now paying great attention to the new Omicron virus. This is because the mutation is only in the spikes. can collect from Mutations already occurring in alpha, beta, and delta strains also add 30 additional mutation sites, as shown in the figure.
However, what must be answered now is
1 Is this virus contagious and easy to spread?
From looking at the genetics of this virus evolved from the delta species that is easily spread at least the spread of the disease It should not be less than the Delta species.

2 Severity of COVID-19
Based on information obtained from South Africa preliminary in many families Found that this species has few symptoms. in both vaccinated and unvaccinated groups By the nature of the virus that spreads easily. The virus itself wants to live long. or propagate for a long time in past studies for other viruses that has been passed on to offspring for a long time or cultivating from generation to generation will find that the violence will decrease In the past, the vaccination method was used because it was fed 30-40 times continuously to get a weakened virus. and then used to make vaccines such as live polio vaccine
However, this virus is too new to say whether the symptoms of the disease have decreased or increased. Must look at the number of patients who need to be hospitalized, treatment results, mortality rates. length of hospital stay Compared to existing species such as the Delta species

3 Laboratory examinations
Is the diagnostic genetic test known as RT-PCR still working?
But from considering the genetic code At least most laboratory tests use at least one N gene. The position of the N gene is relatively stable. no effect on examination However, it may be effective for testing in the RdRp gene depending on the design being used.
at the center’s laboratory doing now when compared according to the genetic code I found that it can still be used well. parts of companies It would have to be examined especially for genes other than N genes.

4 Study of altered genetic location on spikes
very interesting Therefore, it is important to study whether it will reduce the efficacy of single sprite-based vaccines, such as Vector viruses and mRNA, the response to T and B cells. how are you Urgent education is required.
5 preparations for the development of vaccines and treatments
Originally it was thought that the second generation vaccine would be a Beta strain, but later it was found that the Beta strain was not able to fight the fast-spreading Delta strain.
Delta species do not escape the immunity that was originally used as the Wuhan species, not much. Therefore, the current vaccine is available for Delta strains. The vaccine is not thought to change the species. But now, when it is an omicron species, it will have to wait for study. as well as the efficacy of released monoclonal antibodies. and medications planned for treatment
6 Social communication
There is a great awakening now. Therefore, the information is provided to the general public. It must be accurate, transparent, based on truth, scientific reasoning rather than feelings. in spreading the news Sometimes it has quite a psychological impact. Especially untrue news and bullying in society doesn’t help the overall picture.

7 Scientific Analysis and genetic decoding
In such conditions we need scientific reasoning. and an experiment to answer all the questions Genetic transcription must continue and multiply. to be able to be vigilant For Thailand in the past to the present, almost 2 years, about 6,000 genetic codes have been decrypted throughout the body, which is not much if compared to the number of cases of 2 million people.
Now the main genetic decoding will be at the Department of Science that can do a lot In the medical school institution is an add-on. for the center Only 30 whole genes per month will be decoded, and parts of the sprite will be removed. many more In addition, the development of breed-specific testing is very fast. It has always been developed. Species detection can be done from the specific detection. Detect the location of genetic diversity with full decryption The center has always done surveillance in Thailand.
8 new species that spawn when evading immunity
It will reduce the effectiveness of the vaccine. But that’s not to say that vaccines aren’t effective at all. For example, vaccines used to be 90 percent effective, new strains may be reduced to 70-80%, so vaccination is still a must. as much as possible And everyone aged 12 and over should be vaccinated to prevent illness and death. because we already know This virus is definitely not going away. If everyone has immunity Even if it is partial, it will reduce the severity of the disease. Reduce hospitalizations and deaths It will make you look at this infection as a common respiratory disease.
9. Travel Surveillance In the past, we already know that if traveling by air, we have measures to take good care. In the past, either the G breed or the English Delta breed. Enter Thailand by walking in. whether walking to the west coast or the east coast of Thailand Or maybe come swimming. Most will not fly because we already have strict measures
10 In times of epidemic everyone must help each other.
Everyone must have discipline. Respect the rules and regulations that the Ministry of Public Health has laid down the rules including following and hygiene must be strict such as washing hands wearing a mask The distance setting must still be strictly adhered to.
For the situation of covid-19 (covid-19) infection in Thailand on November 29, 2021, the “economic base” follows information from the Center for Coronavirus Disease 2019 (COVID-19) Epidemic Management Center or Prof. The government found that the total number of infected people increased by 4,753.
Cumulative patients (since April 1, 1964) 2,082,703 cases, 27 additional deaths, 6,165 recoveries, 77,811 treatments, 1,985,595 cumulative recoveries (since April 1, 64) 1,985,595