The supplement (Equelle, Pharmavite) depends on S-equol, intestinal bacterial metabolite of the daidzein soybean isoflavone2 requiring estrogen receptors to be selected in the body. With this bond, S-equol helps to ease hot flashes and muscular pains associated with menopause.
This product is not intended to diagnose, treat, cure or prevent any disease, according to Pharmavite.1
"Thousands of women suffer from menopause symptoms such as hot flashes, night sweats, sleep issues, pine changes, vaginal dryness, muscle aches and so much more," said Tara Allmen, MD, Certified Gynecologist of the Board and Author of the menopause Secret, in the form of prepared statements.1
The manufacturer recommends 2 tablets taken twice a day with a glass of water to help relieve these symptoms of menopause. A 1 month supply makes online provision for $ 39.95.1
"We are delighted to launch Equelle here in the United States, after a proven track record in Japan, to address the real needs of women," said Dr Susan Hazels Mitmesser, Vice President of Science and Technology, in a prepared statement. .1 "We are committed to providing nutritional solutions supported by scientific research to help them do their best during this transition."
According to the manufacturer, who also produces Nature Made vitamins, the S-equol supplement has clinical data to support its efficiency and safety, but the FDA has not evaluated Pharmavite's claim that the product mitigates menopause symptoms. The clinical studies showed that no major adverse events were reported, and the company confirms that the active ingredient is safe in food and drug supplements.1
The US study assessing a hot float found that S-equol had significantly reduced symptoms, but the study did not contain a placebo group. However, there was positive control. Results of this study, published in the Journal of Women's Healthit recommended that equity producers would be more likely to benefit from soy food consumption than non-producers for both cardiovascular disease and osteoporosis, although the data is inconsistent.2
According to the US study, the safety data confined to S-equol does not indicate concern, but further studies are needed before definitive conclusions on its effectiveness in relation to vasomotor properties commonly associated with the menopause.2
Menopause can take up to 7 years. It begins with perimenopause as estrogen production starts to fall and periods are irregular. When a woman has gone for a year without a menstrual cycle, she is officially hit by menopause.1
Approximately 6000 women in the United States reach menopause every day and some 85% of women experience symbolic symptoms. Hot flashes are the most common menopause symptom and these are the second most common in perimenopause with 75% of women in the United States suffering from this symptom.1
- Introduction of EQUELLE®: New Hormonal Supplement for Symptomatic Menopause Relief t [news release]. West Hill, CA; April 11, 2019: Pharmavite. https://prnmedia.prnewswire.com/news-releases/introducing-equelle-a-new-non-hormonal-supplement-for-menopause-symptom-relief-300830024.html. Access April 11, 2019.
- Utian WH, Jones M, Setchell KD. S-equol: a potential non-malignant agent for symptom relief related to menopause. J Women's Health (Larchmt). 2015 March; 24 (3): 200-8. doi: 10.1089 / jwh.2014.5006. Epub 2015 February 18. https://www.ncbi.nlm.nih.gov/pubmed/25692726. Access April 11, 2019.
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