New Type of Vaccine Successfully Developed to Treat Autoimmune Diseases
A groundbreaking study published in the esteemed academic journal ‘Nature Biomedical Engineering’ reports the development of a novel vaccine that shows promising potential in preventing and treating autoimmune diseases such as multiple sclerosis, type 1 diabetes, and Crohn’s disease. The research team from the Pritzker School of Molecular Engineering at the University of Chicago unveiled this remarkable breakthrough.
Unlike conventional vaccines that stimulate immune cells to target and eliminate infected cells or produce antibodies to neutralize viruses, this new “reverse vaccine” deactivates immune cells. By doing so, it has the ability to generate regulatory T cells that counteract abnormal immune cells responsible for attacking healthy cells and weakening the immune response.
To test its effectiveness, the research team administered the reverse vaccine to mice with a disease resembling multiple sclerosis, known as autoimmune encephalomyelitis. In this condition, the immune system mistakenly attacks myelin, a protective substance encompassing nerve cells in the spinal cord and brain. Remarkably, the vaccination prevented the immune system from assaulting myelin, resulting in the preservation and restoration of nerve cell function.
Traditionally, autoimmune diseases have been managed through non-specific immune suppression rather than specific control tailored to each disease. However, this innovative reverse vaccine offers a targeted approach without compromising the overall immune system. Furthermore, unlike current immunosuppressive treatments that necessitate long-term usage, this vaccine provides long-lasting efficacy with continued effectiveness even after administration.
Experts speculate that the reverse vaccine could potentially address the vulnerability to infections that occur after immunosuppressive treatment by desensitizing specific immune cells instead of suppressing the entire immune system. The research team intends to conduct clinical trials on multiple sclerosis and celiac disease, as well as non-clinical research on other autoimmune diseases such as type 1 diabetes, allergic asthma, and food allergies.
This groundbreaking development paves the way for revolutionary advancements in the treatment and prevention of autoimmune diseases. The potential of the reverse vaccine to offer targeted therapies while minimizing unwanted side effects is indeed a significant step forward in medical science.
*Today’s Medical Correspondent: Jaebaek Choi (jaebaekchoi@naver.com)*
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▲ Research results have shown that a new type of vaccine has been developed that can completely prevent autoimmune diseases. (Photo = DB)
[메디컬투데이=최재백 기자] A new type of vaccine has been developed that can completely treat autoimmune diseases.
Research results showing the development of an inverse vaccine, a new type of vaccine that can prevent and treat autoimmune diseases such as multiple sclerosis, type 1 diabetes and Crohn’s disease, were published in the academic journal ‘Nature Biomedical Engineering’. published.
A research team at the Pritzker School of Molecular Engineering at the University of Chicago announced that they have developed a new type of vaccine that can completely prevent autoimmune diseases.
Unlike ordinary vaccines, which activate immune cells to kill infected cells or produce cells that produce antibodies that can bind and neutralize viruses, the ‘reverse vaccine’ developed by the research team deactivates immune cells .
According to the research team, the inverted vaccine can generate regulatory T cells that inactivate abnormal immune cells that attack normal cells and weaken the immune response.
The research team injected the inverted vaccine into mice with autoimmune encephalomyelitis, a disease similar to multiple sclerosis.
In autoimmune encephalomyelitis, the immune system attacks myelin, which protects nerve cells throughout the body, including the spinal cord and brain. By injecting the inverted vaccine, the immune system was prevented from attacking myelin, thereby damaging nerve cells. recover as the patient is functioning normally.
The research team explained that until now autoimmune diseases have been treated through non-specific immune suppression rather than specific immune control for each disease, but that they are able to treat autoimmune diseases without suppressing the whole body’s immune system using an inverse vaccine. In addition, he added, although the current immunosuppression must be continued for a long period, the vaccine remains effective for a long time and is effective after administration.
Experts speculated that a reverse vaccine could be used to overcome vulnerability to infection after immunosuppressive treatment by desensitizing specific immune cells rather than suppressing the immune system as a whole.
The research team said it conducts clinical trials on multiple sclerosis and celiac disease, and conducts non-clinical research on autoimmune diseases such as multiple sclerosis, type 1 diabetes, allergic asthma, and food allergies.
Today’s Medical Correspondent Jaebaek Choi (jaebaekchoi@naver.com)
[저작권자ⓒ 메디컬투데이. 무단전재-재배포 금지]
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