Newly Discovered Substance Farnesol Can Prevent Age-Related Muscle Loss, Study Finds

Groundbreaking Discovery: Sungkyunkwan University School of Medicine Reveals Anti-Aging Muscle Loss Solution

A research team at Sungkyunkwan University School of Medicine has made a significant breakthrough in the fight against age-related muscle loss. Their recent study highlights the discovery of farnesol, a plant-derived compound, which demonstrates the ability to prevent muscle weakness caused by aging.

This groundbreaking research revolves around the biochemical transformation of a protein called PARIS (Parkin-interacting Substrate) by farnesol. The research team conducted experiments on older mice and observed that PARIS inhibits the activity of PGC-1α, a crucial protein responsible for supporting muscle cell metabolism.

Through their meticulous study, the team managed to develop a treatment that targets PARIS. They discovered that farnesol induces a biochemical modification of PARIS, effectively inhibiting the suppression of PGC-1α activity. Notably, the administration of farnesol to aged mice resulted in increased muscle mass in their legs and stimulated muscle regeneration.

Prior studies have demonstrated that exercise promotes the activity of PGC-1α. Hence, inhibiting this protein’s activity is integral to preventing age-related muscle loss. Additionally, in young mice, farnesol accelerated muscle metabolism and increased the amount of PGC-1α in muscle cells. Remarkably, a month-long experiment involving aged rats fed farnesol exhibited enhanced grip strength and healthier blood sugar response.

Age-related muscle loss, a natural consequence of aging, poses significant health risks. Reduced muscle mass leads to a decline in bodily functions and an increased susceptibility to chronic diseases such as diabetes, ultimately contributing to mortality.

Until now, maintaining a healthy diet inclusive of protein, vitamin D, and omega-3 fatty acids, along with regular exercise, has been the only known approach to mitigate muscle loss. However, Sungkyunkwan University’s research team proposes that combining these practices with farnesol therapy presents a more effective solution to combat age-related muscle degeneration.

The team’s groundbreaking findings were published in the esteemed international journal, ‘Science Translational Medicine,’ solidifying their contributions in the field of anti-aging research.

A research team at Sungkyunkwan University School of Medicine announced that they have discovered a substance that can prevent muscle loss that occurs with aging.

According to the research team, the substance is called farnesol, a plant-derived compound, and it biochemically transforms a protein called PARIS (Parkin-interacting Substrate) to prevent muscle weakness.

As a result of carrying out experiments on old mice, the research team found that the PARIS protein inhibits the activity of PGC-1α, and carried out research to develop a treatment that targets PARIS.

As a result, it was found that farnesol induced a biochemical modification of PARIS and inhibited the inhibition of PGC-1α activity.

In addition, according to the research team, feeding old mice with farnesol applied increased muscle mass in the legs and promoted muscle regeneration.

According to previous studies, exercise promotes the activity of ‘PGC-1α’, a protein that supports metabolism in muscle cells. Therefore, PGC-1α activity should not be inhibited to prevent age-related muscle loss.

Farnesol was also found to accelerate muscle metabolism and increase the amount of PGC-1α in muscle in young mice. In an experiment where aged rats were fed farnesol for a month, the rats’ grip strength became stronger and there was a healthier response to blood sugar.

As you age, your body loses muscle mass as a natural part of aging. When muscles are reduced, body functions decline and the risk of developing chronic diseases such as diabetes increases. It is also associated with deaths.

To reduce this muscle loss, the only known methods so far are to maintain a healthy diet that includes protein, vitamin D, and omega-3 fatty acids, and exercise regularly.

The research team said, “Maintaining a healthy diet and regular exercise and applying farnesol therapy together will prevent age-related muscle degeneration more effectively.”

The results of this study were published in the international journal ‘Science Translational Medicine’.

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