No effect of vitamin D on statin-related myalgia.

New research has come out that refutes previous studies that vitamin D alleviates the side effects of muscle pain and muscle wasting that can occur when taking statins.

In actual clinical trials involving 2,000 patients, vitamin D showed no effect in preventing statin-related muscle symptoms and stopping statin administration due to side effects.

The results of a study on the effect of vitamin D administration on statin muscle side effects conducted by Professor Mark A. Hlatky of Stanford Medical School in the United States were published in the international journal JAMA on the 23rd (doi:10.1001/jamacardio.2022.4250) .

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Representative side effects of statins, a treatment for dyslipidemia, include new onset diabetes, muscle pain, and muscle wasting. Statin-associated muscle symptoms (SAMS) are common, leading to discontinuation of statin therapy in many cases.

In a previous observational study, muscle-related side effects were reported to be alleviated when a statin and vitamin D were used together.

A double-blind clinical trial was conducted in which men aged 50 years or older and women aged 55 years or older without cancer or cardiovascular disease who were taking statins were randomized to a vitamin D supplementation group (2000 IU per day, n=1033). ) and a placebo group (n=1050).

The primary study endpoint was the number of days of muscle pain or discomfort, and the secondary was discontinuation of statin therapy due to SAMS.

As a result of the analysis, during the follow-up period of 4.8 years, muscle-related side effects occurred in 317 (31%) in the vitamin D group and 325 (31%) in the placebo group, showing no statistical difference significant. .

When the serum concentration of vitamin D (25-OHD) of the participants was divided into three groups: 30 ng/mL or more, 20-30 ng/mL, and less than 20 ng/mL, there was no significant difference in the incidence of side effects .

“Vitamin D supplementation did not prevent statin-related muscle side effects or reduce the risk of discontinuing statin treatment because of them,” the researchers said. “These results were consistent when grouped by serum vitamin D concentration.”

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