The risk of non-alcoholic steatohepatitis causing diabetes was highest among young women.
The research team of Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Data Management Center (Ryu Seung-ho, Jang Yoo-soo, Kim Ye-jin) analyzed the relationship between non-alcoholic steatohepatitis and diabetes in health examinations and published in the Journal of the American Association for the Study of the Liver (Hepatology).
Non-alcoholic steatohepatitis is known to be a major risk factor for type 2 diabetes, but there is no specific report on the differences according to gender and menopausal status.
The subjects of this study were 245,054 non-diabetic adults who had health checks (2011-2018). They were divided into three groups according to gender and menopausal status: males (n = 130,286), premenopausal women (n = 109,810), and postmenopausal women (n = 4,958).
They were followed for 5.3 years, and the risk of developing diabetes was compared according to the presence or absence of non-alcoholic fatty liver disease.
As a result, non-alcoholic fatty liver disease was 4.6 times highest in premenopausal women. In postmenopausal women and men, it was 2.7 times and 2.2 times, respectively. The higher the severity of non-alcoholic fatty liver disease, the higher the risk.
Regarding the results of this study, Professor Ryu explained, “Non-alcoholic fatty liver disease was reconfirmed to be an important predictor of diabetes, and the effect was found to vary greatly depending on gender and menopausal status. “
He added, “It suggests that the gender difference in the presence or absence of non-alcoholic fatty liver needs to be considered for the effective prevention and management of diabetes.”
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