‘OO control’ after menopause reduces the risk of breast cancer

Professor Kang Dae-hee’s research team from Seoul National University, tracking 70,000 people for 9 years

A research team led by Professor Kang Dae-hee from the Department of Preventive Medicine at Seoul National University College of Medicine confirmed that high diastolic blood pressure level in middle-aged menopausal women can indicate the risk of breast cancer by following a large scale. -up. [사진=게티이미지뱅크]

It has been pointed out that regular control of blood pressure can reduce the risk of breast cancer, the cancer with the highest number of cases among women. This is because a large-scale follow-up study has confirmed that high diastolic blood pressure (diastolic blood pressure) in middle-aged women can indicate the risk of breast cancer.

Professor Kang Dae-hee’s research team at the Department of Preventive Medicine at the Seoul National University College of Medicine published a study that confirmed the link between diastolic blood pressure and breast cancer in middle-aged women between the ages of 40 and 69.

The research team followed 73,031 middle-aged women (858 of whom had been diagnosed with breast cancer, 1.17%) for an average of 9 years between 2004 and 2013. As a result, when the diastolic blood pressure was as high as 85 to 89 mmHg, the risk of developing breast cancer was on average 1.40 times higher than normal (less than 85 mmHg).

Specifically, when the risk was analyzed before and after menopause (menopause), the risk of developing breast cancer increased 1.73 times in women with high diastolic blood pressure after menopause. On the other hand, the same level of risk was not found in women before sex. In the case of systolic blood pressure (systolic blood pressure), no significant association was found between the incidence of menopause and breast cancer.

In terms of these results, the research team noted that high blood pressure and menopause further promote cardiovascular changes that negatively affect blood flow with aging.

As we age, arteries lose their elasticity and become stiff (hardening), which prevents smooth blood circulation in peripheral blood vessels, including the breast. This results in the circulatory process not properly handling waste and inflammation that builds up in peripheral blood vessels such as the breast, leading to an environment where tumors or abnormal cells can proliferate. In the case of high blood pressure, it usually speeds it up by making the arteries stiff.

Effects of aging, menopause, and hypertension, respectively, on the incidence of breast cancer presented by Kang Dae-hee’s research team at Seoul National University School of Medicine. [자료=사이언티픽 리포트]

The link with menopause is a result of the cardiovascular protective function of the female hormone estrogen. Estrogen dilates blood vessels to improve function and regulates the amount of lipids (such as cholesterol) in the blood. Therefore, in general, middle-aged menopausal women have an increased incidence of metabolic syndrome and arteriosclerosis, including obesity and hypertension.

For the same reason, breast fat tissue increases in women after menopause, and it is assumed that this increased fat cell leads to an increase in the secretion of ‘estradiol’, a follicular hormone known to cause cancers’ the breast, urethra, and prostate. .

In this regard, diastolic blood pressure, not systolic blood pressure, is associated with breast cancer risk. Diastolic blood pressure is the rate at which the heart draws blood from the veins as it expands. When the diastolic blood pressure is higher than the systolic pressure, it means that the heart is not pumping enough blood. In this case, the blood flow to the peripheral blood vessels is further reduced, so it is inevitable that the abnormal tissue and waste processing function of the body is reduced.

Professor Kang said, “Although systolic blood pressure is often considered more important in blood pressure control, this study shows that diatom blood pressure control is also important for postmenopausal women.” It was said to be ~15% higher, so consistent blood. weight management can be of great benefit in preventing cancer.”

The results of the research were published in the international scientific journal ‘Scientific Reports’.

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