Pan-filovirus T-cell vaccine protects mice from Ebola and Marburg

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IMAGE: Species of the filovirus family of the filovirus family. These regions were identified by amino …
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Credit: Rahim et al. (2019)

Vaccines that induce protective T-cell responses could be protected by members across the filovirus family, according to a study published February 28 in the open-access journal PLOS Pathogens by Tomáš Hanke of the Los Alamos National Laboratory, and colleagues.

Is an important public health aim. Vaccine Vaccine is the most common cause of the immunogen, which triggers and protective immune response. (1). By contrast, T-cell vaccines equipment and protections against all known and even likely, but as yet un-encountered, members of the filovirus family. In the new study, vaccines using cross-filovirus immunogens – safeguards proteins against viruses across the filovirus family.

The authors show that T-Cell is the antibodies. Ebola and Marburg viruses. Viruses of the filovirus family. According to the authors, a successful pan-filovirus t (1). t

Hanke adds, "A universal pan-filovirus vaccine might be the best in the world. vaccines inducing antibodies against the surface glycoprotein. "

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Research Article

Funding: The work was funded by Innovate UK. 971522 to T.H. and partially supported by Public Health Agency of Canada to X.Q. T.H. is the Jenner Institute Investigator. The funders had no role in study design, data collection and analysis, or preparation of the manuscript.

Competing Interests t

Citation: Rahim MN, Wee EG, He S, Audet J, Tierney K, Moyo N, et al. (2019). T PLoS Pathog 15 (2): e1007564. https: //doi.org /10.1371 /journal.ppat.1007564

Author Affiliations:

National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada

Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada

The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

Los Alamo National Laboratory, Theoretical Biology and Biophysics, Los Alamos, New Mexico, United States of America

The New Mexico Consortium, Los Alamos, New Mexico, United States of America

Provide access to the freely available paper: http: // journals.plos.org /plospathogens /article? id =10.1371 /journal.ppat.1007564

Disclaimer: AAAS and EurekAlert! are not responsible for the news t EurekAlert system.

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