[공감신문] Medical staff reporter Choi Chi-seon = Pfizer Korea Pharmaceutical(President & CEO Dongwook Oh)is past 5month 24Work ‘From Pandemic to Endemic, Management of pneumococcal disease burden according to the situationconducted on the subject of ‘IDIS (Infectious Disease Summit) Week’ announced that a webinar was held.
5month24from day 27up to day 4This daily event IDIS Week The webinar was held for a number of prominent infectious disease experts at home and abroad.. Professor Heo Joong-yeon of the Department of Infectious Diseases at Ajou University Hospital, who was a speaker, opened a webinar on the topic of the latest knowledge on the prevention of pneumococcal disease based on the data on the burden of pneumococcal disease for adults in Korea..
Among bacterial community-acquired pneumonia occurring in adults in Korea, pneumococci 27%from max 69%It is the most important causative agent of pneumonia. Pneumonia is the leading cause of death from respiratory diseases in Korea. 1with stomach disease 2020only in years 2only 2Thousands died. Pneumococci not only infects pneumonia, but also infiltrates the blood and meninges, causing bacteremia., It can cause invasive pneumococcal disease such as meningitis., Even if they survive, there is a high possibility of leaving neurological sequelae, so special attention is required..,
To prevent these pneumococcal diseases, the current pneumococcal vaccine that can be vaccinated in Korean adults is23A polysaccharide vaccine and There are two types of conjugate vaccines. double Polysaccharide vaccine 2013through national vaccination 65Supported for ages 3 and older.nevertheless, Number of deaths due to pneumonia 10has steadily increased over the years 2020According to the annual cause of death statistics, pneumonia was the cause of death 3recorded above.
In addition, Recent KCDC research(2018-2021)According to, pneumococci Serotypes included in the conjugate vaccine, Especially 3, 19A It has been reported that the domestic pneumococcal disease burden by serotype is high..
Professor Huh Joong-yeon is one of the serotypes that cause invasive pneumococcal disease in Korean adults through a domestic pneumococcal serotype analysis study recently announced by Korean medical staff. 3 (n=16; 13.8%)class 19A (n=11; 9.5%) serotype is the most common cause.
In addition, Among the serotypes that cause domestic non-invasive pneumococcal pneumonia as well as domestic invasive pneumococcal disease, 3(n = 18, 10.5%)19A(n = 14, 8.2%) emphasized that serotypes have a high disease burden.
actually serotype 3class 19Ais known to have different characteristics from other serotypes.. serotype 3has a unique capsule-type structure with a thick protective polysaccharide coating compared to other serotypes., Less immunogenic and more toxic than other serotypes.
Therefore, the serotype 3Pneumococcal disease caused by, Associated with risk factors for death from invasive disease. In addition, serotypes found in Korea 19AMost of these are antibiotic-resistant strains, and it has been analyzed that caution is needed to reduce the risk of serious diseases that can lead to death..
Professor Huh Jung-yeon “pneumococcal infection is 50Incidence and fatality rate increase”as “Care should be taken to prevent pneumococcal pneumonia caused by serotypes with high domestic disease burden., Efficacy through large-scale clinical trials Vaccination with a proven pneumococcal conjugate vaccine should be considered.”said.
Professor Huh Jung-yeon submitted a thesis1Conjugated vaccines and vaccines for domestic adults who participated as authors, Sequential inoculation of polysaccharide vaccine*According to a study evaluating the effectiveness of 65aged over 74Conjugate vaccines in adults under the age of 66.4%(95% CI 0.8-88.6), Polysaccharide vaccine 18.5%(95% CI 38.6-52.0)showed the effect of, When both the protein conjugate vaccine and the polysaccharide vaccine are inoculated in any order 80.3%(95% CI 15.9- 95.4)recorded the effectiveness of the vaccine. It is recommended that both pneumococcal vaccines be administered in any order. 65aged over74It was analyzed as the most effective way to prevent pneumococcal community-acquired pneumonia in adults under the age of one..
Heejin Kim, Executive Vice President, Vaccine Division, Pfizer Korea ”Through this webinar, we were able to understand the importance of pneumococcal conjugate vaccine based on evidence such as epidemiologic and vaccine effect studies in Koreans.”as “Pfizer Korea will continue to take the lead in preventing pneumococcal disease in Korea based on more diverse evidence.”said.
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