Recent studies discover Ebola gene differences in DRC outbreaks

Today Lancet Infectious Diseases It published two new studies showing how the response to the current Ebola outbreak in the Democratic Republic of the Congo (DRC) was created by the lessons from the West African outbreak of viral disease from 2013 to 2015.

In a separate development, the DRC's health ministry reported nine new infections today, part of the ongoing rise of cases.

The novel pressure encouraged an earlier outbreak

In particular, the DRC used domestic genomics to provide real-time analysis of the virus. In 2018, the DRC had the Ebola race from 9th and 10th, which was significantly different in size and scope.

The newly published studies prove that the virus limbs responsible for the current outbreak, the second largest in the world, are genetically different from a smaller outbreak in the western reaches of DRC which ended in July 2018.

From the earlier outbreak, involving 54 cases, Placide Mbala-Kingebeni, MD, and colleagues of 17 genres of Ebola (EBOV) ordered the new pressure called "Tumba." This outbreak had a 60% death rate, such as the West African outbreak. The Tumba type of the virus, however, was not as susceptible to current Ebola treatment.

"We demonstrate the possibility of using genomics to quickly characterize new Ebola viruses within an outbreak time," concludes the authors of the study.

A second study, also written by Mbala-Kingebeni and his colleagues, focused on coding two Ebola virus genomes collected 5 days after the current outbreak, in the DRC's KCU and Ituri North provinces. A 62% case death rate at the current outbreak, the highest rate of any documented Ebola outbreak.

The authors found that this outbreak was not caused by the Tumba strain of Ebola virus, and was more susceptible to monoclonal antibody therapies (mAb114 and ZMapp), which are currently being used as treatment options.

Commentary on this study, a group led by Anise Happi, a PhD from the University of Ibadan in Nigeria, said that work with genomic math establishments supports national and regional infectious diseases in regions at high risk of outbreaks "Therefore a possible one-step solution would be made. to break down known and novel pathogen pathogens rather than the need for multiple individual pathogen tests. "

Outbreaks grow to 1,273 cases

According to the daily update of the health minister, the DRC today confirmed 9 new cases, including 3 in Katwa and Butembo points, and one in Masereka, Mandima, and Kyondo, raising the total of the cumulative outbreak to 1,273 cases, with including 821 deaths. Seven deaths of confirmed cases were noted today, including four community deaths.

The DRC also updated its epidemiological assessment of the outbreak, focusing on the week commencing April 8. Since then, 54.5% of the 110 newly certified cases have come from Katwa.

"There has been a significant increase in the number of new cases announced weekly over the past 5 weeks after targeted attacks against Katwa and Butembo CTEs" said the ministry of health.

Of the 83 deaths recorded last week, 49 people were community fatalities, or 59%, and 34 were in a treatment facility.

Vaccination efforts continue, with 101,249 people vaccinated with rVSV-ZEBOV, including 26,316 in Katwa, 2259 in Beni, 12,447 in Butembo, and 6,556 in Mabalako.

Today, Felix Tshisekedi, DRC president, visited the Ebola treatment center in Beni, and made a speech asking the local community to work with outbreak response workers.

See also:

Apr 16 Lancet Infect Dis study

Apr 16 Lancet Infect Dis North Kivu Study

Apr 16 Lancet Infect Dis commentary

April 16 Update of the DRC

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