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Reduced muscle strength increases the risk of non-alcoholic fatty liver and liver fibrosis

Studies have shown that as body strength decreases, the likelihood of developing non-alcoholic fatty liver and developing liver fibrosis increases.

(From left) Professor Won Kim and Bokyung Koo at Boramae Hospital

Boramae Hospital’s Gastroenterology Department Professor Kim Won-Endocrine Metabolism Department Professor Bo-kyung Koo’s research team is based on the clinical data of 13,050 people (average age 45.6 years) who participated in the National Health and Nutrition Survey (KNHANES) from 2014 to 2016. We presented the results of analyzing whether there is a significant association between the incidence of liver disease.

The research team used the value obtained by dividing the subject’s grip strength by the body mass index (BMI) as the muscle strength, and the prevalence of non-alcoholic fatty liver and liver fibrosis in the subject through the fatty liver index and liver fibrosis biomarker (BARD, FIB-4) values. Derived.

As a result, it was found that muscle strength decrease significantly increased the risk of developing non-alcoholic fatty liver and liver fibrosis.

When analyzing the prevalence of non-alcoholic fatty liver by group by dividing the subjects into 4 groups according to muscle strength, the prevalence of the highest group was only 7.5%, whereas the prevalence of the lowest group was 45%, which was about 6 times different.

Similar results were found in the liver fibrosis analysis. The progression of liver fibrosis confirmed through the BARD analysis was more than twice as high in the lowest group (63.9%) compared to the highest muscle strength group (29.7%), and two groups in the FIB-4 analysis. A whopping 7-fold difference was confirmed between the two (2.6% vs 18.0%).

In addition, as a result of multivariate analysis in which the confounding variable was controlled, the risk of developing non-alcoholic fatty liver due to decreased muscle strength increased by up to 1.6 times and the risk of liver fibrosis progression by up to 1.35 times. It was judged to have a connection

Prof. Won Kim said, “Through this study, we have confirmed the possibility that decreased muscle strength due to aging, etc. increases the risk of non-alcoholic fatty liver and liver fibrosis.” It is estimated that it has had some effect on the outbreak.”

He also advised, “In old age, when physical strength is greatly reduced, minimizing the loss of muscle strength by continuing exercise and dieting at the same time can be very helpful in maintaining liver health.”

Meanwhile, the research results were published in the July issue of the journal of cachexia sarcopenia and muscle.

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