The largest study was carried out on deep brain stimulation in the brain reward system providing continued relief which patients can use as a form of severe depression treatment?
Published in the journal Neuropsychopharmacologypatients suffering from serious treatment-resistant depression can benefit not only sharply but from start to finish with deep brain stimulation, as researchers from the Medical Center – Freiburg University and their colleagues from Bonn Hospital, show. current study. t Could it really be a form of severe depression?
Deep brain stimulation and electrodes
The team used thin electrodes to encourage a deep part of the reward system in a 16 patient brain. As a result, depression intensity ratings in all patients were greatly reduced, by an average of half.
Half of the study participants were reduced even below the level deemed to be a depression threshold requiring treatment. The majority of patients received these positive stimulation effects within the first week, and lived during the year study.
Professor Dr. Thomas Schläpfer, head of biological psychiatry mediator at the medical center, Freiburg University: “The strongest result from the study is the continued effectiveness of very ill patients.
“Most treatments do not become effective psychiatry after months and years, we have shown for the first time in a relatively scaled study that deep brain stimulation is a real option for those patients suffering from severe depression that is resistant to treatment. .
Finally, a successful form of severe depression treatment
It is estimated that 10 to 30 per cent of all people with recurrent depression do not respond to approved treatment. It may be a treatment option for some of these patients with deep brain stimulation. The 16 participants in the FORSEE-II study suffered severe depression for 8 to 22 years and had 18 drug therapy, 20 electrovulsive therapy, and 70 hours of psychotherapy – without success.
The researchers put the brain deep stimulation systems into the patient's cavity measure of the brain and used them to stimulate the medial silt basin. This brain region is concerned with the understanding and regulation of pleasure and reward and is therefore also significant in terms of the perceived motivation and quality of life.
Serious depression treatment may be permanent
The doctors evaluated the success of the therapy monthly with the help of the Montgomery-Asberg Depression Rating Scale (MADRS). MADRS scores of ten study participants had already decreased significantly within the first week and remained at a low level.
Schläpfer says: “Our patients have struggled with severe depression for years without any signs of improvement. Deep brain stimulation provided significant relief for most of them within days, which lasted during the therapy. Other types of treatment such as medication and psychotherapy often lose their effectiveness during time.
“It is certainly very substantial in terms of the study's data that the effect seems to be long-lasting, and the positive effects continue for years”.