◀Anchor▶
Of course, it is an organ abnormality in severe cases
Rheumatoid arthritis with cognitive impairment
Meanwhile, the focus has been solely on relieving inflammation.
There was
Cognitive impairment and cognitive impairment
Treatment at the time opened the way.
Treatment includes dementia drugs in clinical trials
It’s getting more and more attention.
Reporter Cho Hyung-chan reports.
◀Report▶
Rheumatoid arthritis is both genetic and environmental
Beyond immunity, we need to protect our body
Inflammation and inflammation as immune cells flock to the joints
It is an autoimmune disease that causes damage.
Scleritis, interstitial pneumonia, and purpura
In parallel, the inflammatory response also affects the brain,
It can cause depression and cognitive impairment
The cause was a labyrinth.
The Korean research team found that patients with rheumatoid arthritis
Coexistence of synapses and stellate cells in the brain
Maobi enzyme is the common pathogenesis of both diseases
He was the first to discover that he was a human being.
Maobi inhibits signal transduction in nerve cells.
It activates a neurotransmitter called GABA.
If ‘KDS2010’, which inhibits Maobi, is administered, arthritis as well as cognitive function will be recovered.
will
Woojin Won / Researcher, Social Cognitive Center, Foundation for Basic Science
“Previous studies have shown that immune cells and
If the focus was on reducing the inflammatory
The target mechanism has now been revealed.”
This has also been confirmed through animal experiments.
KDS2010 is currently used for Alzheimer’s and other dementias.
It is getting more attention as it is undergoing clinical trials as a treatment
There are.
Treating arthritis, cognitive impairment and dementia at the same time
The duration of the development of a possible next generation rheumatoid treatment
It is open.
Chang-Jun Lee / Director, Center for Cognitive and Social Studies, Foundation for Basic Science
“In dementia, we discovered that the Maobi of reactive star cells
Because enzymes have been shown to be the cause
When this is prevented by the same mechanism
Rheumatoid Animals as Animal Models of Dementia
Cognitive impairment was improved by restraint in the model
It’s done.”
The results of this study were published in the top 10 molecular medicine journals in the world.
Official Journal of the Korean Society for Biochemical and Molecular Biology
It was published in ‘Experimental Molecular Medicine’.
This is Jo Hyung-chan from MBC News.
(Video broadcast: Shin Shin-ho)
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