Medical Genome Center cooperate with “international researcher” decoding the genetic code of infected people in the whole genome (23 pairs of chromosomes, 25,000 genes from 3 billion bases) to solve the problem. Along with decoding the entire genome of the 2019 coronavirus (30,000 bases), past research shows that people infected with virtually all types of virus, including the 2019 coronavirus, are most likely asymptomatic. (asymtomatic) or mild (mild) symptoms are severe and some are fatal. (life-threatening) when the virus invades the body of an infected person. The “viral genome” stimulates the infected cells. such as lung cells to produce proteins to immediately resist specific (against all virus strains), which is known as “Interferon (IFN)” with the effect of blocking the proliferation of the virus. Interferon is a substance made by the body before antibodies to fight the virus, making most people infected with the virus often asymptomatic. or have mild symptoms
Recent research reveals that more than 20 percent of people with severe COVID-19 It was found that in the body there was “Antibodies to one’s own body (Auto-antibodies) ” Destroy “Interferon” and the amount of Auto-antibodies. Will increase with age and is more common in people over 70 years of age and more common in men than women. About 3.5 percent were found to be infected with inborn errors, causing the body to make fewer interferons compared to normal people. or not build at all In both cases, the body of the infected person produces less interferon. This allows the virus to multiply rapidly without any inhibition, causing severe infections (Figure 3-4). Interferon may be given to people with the condition. “Interferon is defective”, it is possible.
A global team of infectious genome research is now evaluating whether a combination booster vaccination that helps people not become severely ill and fatal will compensate for the inborn mutation of infected people who transmit it. This results in primary immunodeficiency and the generation of Auto-antibodies. Is it possible to resist interferon in the elderly resulting in severe coronavirus disease 2019 infection?
In addition to 20 + 3.5 percent of people with COVID-19 We now know the cause (Figure 5). Scientists around the world are trying to determine the other 80 percent of the causes for severe COVID-19 symptoms. One, whether “children, young people or the elderly”, is resistant to coronavirus (Resistant to COVID-19 infection) even when co-existing with a severely coughing and sneezing infected person. together for a long time even if not vaccinated or vaccinated This has led to the emergence of the “COVID Human Genetic Effort” project, an international collaborative project that helps decode the human genes of all (25,000 genes) or the entire genome (3 billion). bass) focuses on two main groups, namely The first group is those who are resistant to coronavirus disease 2019 and the second group is the one with severe infections. that any gene mutation is involved
by comparative examination in the population of each race to see if there was a mutation “On the same gene” and “on the same location of that gene” or not? In order to use the knowledge gained to develop new drugs or to screen people at high risk of severe infection to receive antiviral drugs or drugs quickly in time for the most effective treatment.
In conclusion “Auto-antibodiesis the second risk factor thatpeople infected with COVID-19 with symptoms that were severe enough to cause death, followed by “age” but higher than the third and fourth place are “sex” and “Congenital mutation (inborn error)that results in primary immunodeficiency
Project “COVID Human Genetic Effort“There are more than 50 genome sequencing centers and hundreds of hospitals around the world, led by Prof. Jean-Laurent Casanova of the university. Rockefeller and Prof. Helen Su from the National Institute of Allergy and Infectious Diseases. (USA) The project participants come from many countries. Many nationalities such as Asia, Europe, Latin America and the Middle East. including the Medical Genome Center, Ramathibodi Hospital from Thailand
Medical Genome Center cooperate with the project “COVID Human Genetic EffortIn a key position on the genome of the Thai and Southeast Asian populations associated with severe coronavirus infection, including mutated genes in infected people resistant to coronavirus infection. 2019 Expect to have good news to report soon. The whole genome transcription of the Medical Genome Center It has developed a long-read human genome sequencing technology to better detect mutational patterns on the human genome.
Thanks FB : Center for Medical Genomics