Stick to “BQ.1.1”, new species. Omicron’s great-grandsons, instead of “BA.5” and “BA.2.75.2”.

23 September ’22 Genome Medical Center Faculty of Medicine Ramathibodi Hospital Mahidol University Post a message via Facebook “Medical Genomics Centre” stating that …

“BQ.1.1”, the great-grandson of Omicron BA.5, had three different backbone mutations of BA.5, R346T, K444T, and N460K, which likely replaced “BA.5” and “BA.2.75. 2.” “

The number of people who are immune to the 2019 coronavirus, both through natural infection and through vaccination, is currently increasing globally. This has led to a significant reduction in the number of new infections and deaths worldwide. Many countries have adjusted their status to COVID-19. endemic

Increasing human immunity around the world has driven the virus to accelerate its mutation in order to survive, especially by changing the cortical part of the virus particles to avoid immunity to spread from person to person as long as you

of collaboration “Scientists around the world in the digital age” have come together to help decode the 2019 coronavirus genome, upload and share it on the global coronavirus genetic code database “GISAID”, allowing us to be aware of the mutation of the virus. around the world in real time

While experts around the world are monitoring the outbreak of omicron subspecies “BA.2.75.2”, the first case was detected in India and has spread globally, replacing BA.5 and BA.4.6. Slowly, “a new great-grandson of Omicron BA.5” was soon found in England, called BA.5.3.1.1.1.1(.1) or “BQ.1.1” (Figure 1).

A super-mutated subspecies likely to replace the main Omicron BA.5 strain now spreading worldwide is:

BA.5.3.1.1.1.1(.1) / BQ.1.1

BA.2.3.20

BA.2.75.6.1 / BY.1

BA.2.75.5.1 / BN.1

BA.2.75.2

BA.5.2.1.7 / BF.7

Experts around the world are most focused on BQ.1.1 as the number of infections is increasing rapidly, especially in the UK the first case was found on August 26, 2022. Now (September 22, 2022) found in The database “GISAID” has 28 cases, of which 78 cases have been found worldwide, sorted by the number of samples found in the UK, USA, France, Australia, Italy, Denmark , Belgium, Japan, Austria, the Netherlands, and Germany (Figure 2 ).

Omicron BQ.1.1, the great-grandson of BA.5, has three spike mutations, R346T, K444T and N460K, which are different from BA.5 (Figure 3), and identical to BA.4 /BA.5 in four 69-70 missing from the genome, L452R, R493Q, and F486V.

Omicron BQ.1.1 mutates on six spike segments, unlike BA.2.75.2, missing 69-70 from the genome, L452R, K444T, G339D, and F486V (Fig. 4).

It can be seen that the location of the mutations on the spikes in each subspecies has started to be similar. In other words, there are variations of “convergent evolution”, ie heterogeneous species, but similar features such as the wings of birds, insects and bats have evolved in response to adapt to specific environments. (avoid immunity)

Omicron BQ.1.1 has not been found in Thailand.

BQ.1.1 has a relative growth advantage than BA.5 about 5.3 times (531%) (Figure 5) and has more relative growth advantage. BA.2.75.2 is about 3.2 times (327%) (Figure 6), which is considered to be the fastest spreading omicron subspecies in the world at the moment. Severity of infection was not significantly different from BA.5.

https://www.biorxiv.org/content/10.1101/2022.09.15.507787v1

Leave a Reply

Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.