The need for surgery for varicose veins in the lower extremities, predictable by genetic risk score

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In patients with varicose veins, the genetic risk score can now predict the need for surgery. [사진=게티이미지뱅크]

For the first time, a genetic risk score that predicts the likelihood of patients suffering from varicose veins requiring surgery has been identified. Based on the largest international study ever, a team of researchers from Oxford University in England found that the possibility of surgery for varicose veins in the lower extremities is related to genetic factors. This could potentially lead to new treatments.

Varicose veins are a very common symptom in chronic venous disease. In the West, it is known that more than 3 out of 10 people are affected. If left untreated, it can worsen into a number of health complications, including leg ulcers and ultimately amputation.

The Oxford University research team investigated which traits were linked to which genes by analyzing the whole genome of 401,656 people with varicose veins in the UK Biobank and cloning the genes of 408,969 people at 23andMe, an American biotechnology company. The results identified 49 genetic variants that increase the risk of varicose veins in the lower extremities. The research team identified pathways involving the body’s connective tissue and the immune system as major factors in the pathology of varicose veins in the lower extremities.

This research was carried out in interdisciplinary cooperation with Oxford University’s Department of Orthopedics, Rheumatology, Musculoskeletal System, Surgery, and Ministry of Women’s and Reproductive Health. The research team also worked with an American company that conducts genetic testing on consumers to find people who are prone to varicose veins.

“It was very important that the surgeon involved in the research team to identify patients who had more severe symptoms and had already had surgery for this,” said lead author Professor Dominic Furness. We found it with the genome susceptible to

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“This large-scale study brings together new evidence for the genetics underlying varicose veins in the lower extremities, a very common condition in women and during pregnancy,” said Krina Sondervan, director of women’s and reproductive health at Oxford University. It opens up a new path for us.”

The study was published in Nature Communications. The original title is ‘Genome-wide association analysis and replication in 810,625 individuals with varicose veins’.

Reporter Lee Bo-hyun together@kormedi.com

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