This time pig kidneys… First transplant in the US and functional for three days (comprehensive)

Brain-dead genetically engineered pig kidney transplant

‘Good news’ following the recent success of in vitro kidney and heart transplantation

University of Alabama medical staff transplants kidneys from genetically engineered pigs into brains

(AFP = Yonhap News) A scene where medical staff at the University of Alabama in the United States transplant the kidney of a genetically-modified pig into the body of a brain-dead man. Medical staff at the University of Alabama published a paper on the success of this operation in the Journal of the American Society of Transplantation (AJT). 2022.1.20. [email protected] [앨라배마대 제공]

(New York, Seoul = Yonhap News) Correspondent Kang Geon-taek, Correspondent Kim Ji-yeon = The New York Times (NYT) and AP News reported on the 20th (local time) that the first operation in the United States to transplant a kidney from a genetically engineered pig into the body of a brain-dead person was performed. ) reported.

On the 7th of this month, the transplantation of the heart of a genetically modified pig into a human body was successful in the United States, followed by a kidney transplant, which is good news for those waiting for a transplant.

The University of Alabama medical team led by Dr. Jamie Locke removed the kidney from the body of Jim Parsons, 57, a man who was brain-dead in a car accident in September last year, and removed the kidneys from genetically modified pigs through a paper published in the Journal of the American Transplantation Society (AJT). said to have been transplanted.

The operation was performed on September 30, last year, four days after Parsons was diagnosed with brain death.

According to the paper, the pig kidneys started to produce urine 23 minutes after the transplant, and then functioned normally for 77 hours.

During the transplantation process, one of the two kidneys was damaged and the function was slightly weakened, but neither of them were rejected by the human body.

The brain-dead who underwent the operation were not infected with the pig virus, nor were pig cells detected in their blood.

On the 3rd day, the transplant recipient’s body had excessive bleeding due to blood clotting disorders, and the kidney was eventually removed, and the patient died.

Before the operation, the research team used a self-developed histocompatibility test to determine whether surgery was possible.

The success of the operation also verified the validity of the test, the researchers said.

While recent research on pig organ transplantation has yielded successive results, the New York Times reported that this operation is the first result of a kidney transplantation study published in a medical journal that has passed peer review.

Previously, in October of last year, New York University Langon Health medical staff succeeded in transplanting a pig kidney ‘extracorporeally’.

At that time, two of the transplant recipient’s own kidneys were left intact, and one pig kidney was connected externally. This kidney was functioning normally for 54 hours.

It is different from this study in which both kidneys of the patient were removed and two pig kidneys were transplanted.

On the 7th, medical staff at the University of Maryland received attention for transplanting a genetically modified pig heart into the body of a patient with end-stage heart disease. The patient who received the heart transplant is said to be alive and well.

In all of these surgeries, genetically engineered pigs made by Libivcore, a subsidiary of United Therapeutics, were used.

The company’s researchers applied 10 genetic modifications, including removing some genes that trigger an attack on the body’s immune system or cause the animal’s organs to grow excessively.

According to the AP, about 41,000 organ transplants were performed in the United States last year, but it is far from sufficient in that there are more than 100,000 people waiting for organ transplants. Thousands of these people die each year waiting for an organ transplant.

In particular, more than 10 people a day who are waiting for a kidney transplant die without surgery, the New York Times reported.

Dr. Locke, who led the operation, said, “The organ shortage is a crisis that we have never had a solution for.”

Parsons, who received the kidney transplant, was registered as an organ donor, but was not fit to donate and liked to help others, the family said.

“Parsons would have wanted to save as many people as possible,” the family said. “He will be proud that his death can bring hope to others.”

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