Humans have been conducting various investigations for a long time by asking for blobulsa or rejuvenation, and in recent experiments using rats, it has been reported that the blood transfusion of young rats can achieve benefits such as cell regeneration or enhancing natural healing power. In a new study, it was reported that an experiment where old rat blood was transfused into younger rats, which was counterproductive to this attempt, showed signs of aging in younger rats.
In previous studies, injecting the blood of young rats into older rats has been reported to regenerate organs, tissues and brain function. A new research team in Korea and the United States conducted an experiment where blood from old mice was injected into young mice.
The research team prepared 3-month-old mice and 22-24-month-old mice, and transfused the old mice’s blood into the young mice over a period of one week. In addition, as a control group, mice that received blood transfusions from the same young mice were prepared and compared with each other, such as physical strength, muscle strength, and biomarkers.
As a result of the experiment, rats that received blood transfusions from old rats were depleted faster than the control group and could only run a short distance when running on a treadmill, and were confirmed to be inferior to’ the control group in the strength test. . They also report increased levels of biomarkers indicative of kidney and liver damage in rats transfused with old rat blood.
In this study, younger rats were transfused with the blood of older rats, and the older rats showed an improvement in obesity and fibrosis, reducing fatigue and increasing muscular endurance. The research team also carried out an experiment where human kidney cells were placed in plasma collected from an elderly man between the ages of 60 and 70. As a result, within 6 days of starting the experiment, the kidney cells began to release multiple biomarkers indicative of aging. In addition, these biomarkers were not detected when kidney cells were placed in plasma collected from people between the ages of 20 and 30.
From the results of this experiment, the research team believes that there will be a substance called senescence-associated secretory phenotype (SASP) that is secreted from senescent cells that have stopped division acts on young mouse cells to accelerate aging. In this regard, it may lead to the development of new treatment strategies that act on various factors, including SASP, to realize longevity. Relevant information can be found here.