This article was originally published here
Alzheimer’s dementia. 8 October 2020. Doi: 10.1002 / raised 12157. Online before printing.
Vascular contributions to cognitive impairment and dementia (VCID) are characterized by the aging of the neurovascular unit that confronts and fails to cope with biological insults due to systemic and brain vascular diseases, proteinopathy including Alzheimer’s biology, disease metabolic or immune response, resulting in decline. This report summarizes the discussion and recommendations of a working group convened by the National Heart, Lung, and Blood Institute and the National Institute of Neurological Disorders and Stroke to assess the state of the field in VCID research, identify research priorities, and promote collaborations. As discussed in this report, advances in understanding the biological mechanisms of VCID across the broad spectrum of diseases, chronic systemic comorbidities, and other risk factors may lead to potential prevention and new treatment strategies for reducing the burden of dementia. A better understanding of the social determinants of health that influence risks for both vascular disease and VCID could provide insight into strategies for reducing racial and ethnic disparities in VCID.
PMID: 33030307 | DOI: 10.1002 / raised 12157