A recent study conducted by a team of researchers revealed that patients with a rotator cuff tear and vitamin D deficiency may experience an accelerated inflammatory response in the torn muscle. This is due to the effects of vitamin D deficiency on factors associated with muscle atrophy, fatty degeneration, and inflammation.
Investigating the Impact of Vitamin D Deficiency
The team, led by Professor Jeong Seok-won from Konkuk University Hospital’s Orthopedic Surgery department, published these findings in a renowned international orthopedic journal, the ‘American Journal of Sports Medicine’ in August.
According to their research, it is estimated that vitamin D deficiency affects approximately 14% of the general population and is known to be linked to muscle atrophy and reduced immune function. Given this knowledge, the researchers aimed to explore the influence of vitamin D deficiency on muscle gene expression changes in patients with a rotator cuff tear.
Methodology and Results
In their study, the researchers examined a group of 12 patients with both a rotator cuff tear and vitamin D deficiency. This group was compared to another group of 12 patients who had similar characteristics, such as age, sex, and severity of the rotator cuff tear, but had adequate levels of vitamin D. The researchers analyzed the changes in gene and protein expression in the muscle, tendon, and deltoid muscle.
The results of the study showed that vitamin D deficiency had a significant impact on muscle atrophy in the deltoid muscle. Additionally, it was confirmed that the rotator cuff tear had a greater effect on inflammation, as compared to muscular atrophy.
Implications and Recommendations
Professor Jeong Seok-won commented on the significance of the findings, stating that this study is the first to demonstrate how vitamin D deficiency in patients with a rotator cuff tear can further aggravate the inflammatory response in the torn muscle, leading to pain and functional decline. He also suggested that vitamin D supplementation could potentially help improve shoulder symptoms and restore function in these patients.
It is important to note that vitamin D deficiency is a prevalent condition and addressing it may have positive implications for patients with a rotator cuff tear.
[의학신문·일간보사=김현기 기자] They found that vitamin D deficiency in rotator cuff patients can further accelerate the inflammatory response of the torn muscle by affecting factors involved in muscle atrophy, fatty degeneration, and inflammation.
Professor of Orthopedic Surgery Konkuk University Hospital Jeong Seok-won<사진> The team recently published these results.
According to the research team, vitamin D deficiency is common enough to reach 14% of the entire population and is known to be associated with muscle atrophy and reduced immune function.
Given that vitamin D deficiency is a common symptom in rotator cuff tear patients, the research team analyzed how vitamin D deficiency affects muscle gene expression changes in rotator cuff tear patients.
Specifically, the research team studied a group of patients with a rotator ligament tear and vitamin D deficiency (12 patients) and a group of patients (12 patients) who were similar in age, sex, and degree of rotator ligament tear to the patient group this but had enough vitamin D. We analyzed gene and protein expression changes in muscle, tendon, and deltoid muscle.
As a result, it was found that vitamin D deficiency has a significant effect on the muscle atrophy of the deltoid muscle, but it was confirmed that the rotator cuff has a greater effect on the expression of inflammation than the muscular atrophy.
Professor Jeong Seok-won said, “This result is the first study to show that vitamin D deficiency in patients with a rotator cuff tear can further accelerate the inflammatory response of the torn muscle, leading to pain and functional decline.”
He added, “In the case of rotator cuff tears in patients with vitamin D deficiency, vitamin D supplementation helps improve shoulder symptoms and restore function.”
Meanwhile, this study was published in the famous international orthopedic journal ‘American Journal of Sports Medicine’ in August.
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