Whether Wuhan pneumonia patients will evolve from mild to severe, scientists may have found the key underlying factors. Schematic. (Photo by Reuters)
[Compiling Chen Chengliang/Comprehensive Report]According to statistics, about 9% of Wuhan pneumonia (new coronavirus disease, COVID-19) patients with mild illness will worsen to severe illness. British scientists may have identified the underlying factors! They found that when a person is infected with the Wu lung virus, a specific protein called CD47 on the surface of the cells in the body determines the severity of the infection. Researchers believe that this discovery is a very important step in the fight against Wuhan pneumonia.
According to Reuters, researchers from the School of Biological Sciences at the University of Kent and the Institute of Medical Virology at Goethe University found that high levels of CD47 protein prevent effective immune responses, increase disease-related tissue and organ damage, or cause Wuhan The severity of pneumonia is relatively high. Related papers were published in the journal Current Issues in Molecular Biology.
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The function of CD47 protein is to send a “don’t eat me” signal to the immune system to prevent the immune system’s defenses from accidentally destroying healthy cells.
Researchers have found that when cells are infected by the Wu lung virus, the CD47 protein content on the surface will increase, and at the same time it will also increase the level of another protein SIRPalpha. It cooperates with CD47 to induce the immune system to ignore the infected cells, resulting in the production of a large number of viruses. Lead to aggravation of the condition.
According to this study, known risk factors for severe Wuhan pneumonia include advanced age and diabetes, and these diseases are all related to higher CD47 protein levels. High CD47 levels can also lead to high blood pressure, which is an important risk factor for complications such as heart disease, stroke and kidney disease.
The researchers said that further studies are still needed to define the role of CD47 and SIRPalpha in COVID-19 in more detail, but they emphasized that these findings are “exciting” and they may have identified a severe pulmonary virus infection. Important factor, this is a very important step in the fight against Wuhan pneumonia.
At present, treatments for the above-mentioned proteins are already in development. Researchers may find strategies to alleviate the symptoms of most severely ill patients, and further improve the design of treatments.
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