Alcohol Addiction Treatment: A New Approach
London (IT Boltwise)-A new clinical attempt has shown that the dopamine-improving drug Tolcapon can improve self-control and reduce alcohol consumption in people with alcohol addiction.
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A recently carried out clinical attempt has shown promising results for the treatment of alcohol dependency with the medication Tolcapon. This drug, which was originally approved for the treatment of Parkinson’s disease, increases the dopamine availability in the pre-frontal cortex of the brain. This region is crucial for self -control, which is often affected in people with alcohol addiction. The study published in Biological Psychiatry: Cognitive Neuroscience and Neuroimagingshows that Tolcapon increases the activity in brain regions such as the inferior frontal lobe and the dorsolateral prefrontal cortex, which is accompanied by an improved performance in self -control tasks and less alcohol consumption.
Alcohol addiction is a widespread and serious disease, which is characterized by a strong desire for alcohol and a reduced ability to inhibit this request. Previous attempts to treat the disease with dopamine -related drugs had mixed results because these medication influence the dopamine levels in wide areas of the brain. Tolcapon, on the other hand, offers a more targeted approach by inhibiting the enzyme catechol-o-methyltransferase, which is mainly reducing dopamine in the prefrontal cortex.
The study comprised 64 participants aged 21 to 40, which met the diagnostic criteria for moderate or severe alcohol addiction. These participants were chosen random to receive either Tolcapon or a placebo over a period of eight days. The results showed that those who received Tolcapon had improved inhibition control, which was measured by shorter response times during a stop signal task. They also reported less alcohol consumption during the study.
The results of the study are promising because they indicate that a targeted increase in dopamine levels in the prefrontal cortex can restore self -control in people with alcohol addiction. This could be a new therapeutic approach that goes beyond the medication currently approved by the FDA, which mainly aim to reduce the desire for alcohol or to change its acute effects. However, further studies are necessary to examine the long -term effects of Tolcapon and determine whether it can also influence other aspects of alcohol dependency, such as the desire or mood regulation.
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