Amebic Colitis Clinical Features: Beijing Case Series 2021-2024

Here’s a breakdown of⁣ the information provided from the text, focusing on ⁤the pathological ⁣examination and figure details:

Pathological Examination findings:

*‍ ‍ General Findings: Biopsies ‍showed acute and chronic inflammation with ulcer formation. Other common findings included eosinophilic infiltration, cryptitis, and granulation tissue hyperplasia.
* Definitive Diagnosis: Confirmed by identifying amebic trophozoites (see Fig.1M).
* Special ⁢Staining: ⁤Periodic acid-Schiff (PAS) staining was used to further confirm the presence of amebic organisms (see Fig. 1N). A‍ positive PAS stain appears as a purplish-red color.
* Histological ⁤Presentation: Erosions or ulcers ⁣with ⁤”dirty necrosis” were typical ⁢- this is described as liquefactive necrosis with lots of cellular debris and neutrophils.
* Differentiation: Amebic trophozoites were distinguished from macrophages based on their morphology (trophozoites are generally smaller).

Figure 1 Details:

* overall: Figure 1 shows endoscopic and pathological manifestations of the disease.
* ⁣ A-L: ⁢ These panels show endoscopic images of lesions in different parts of the colon:
‍ * ⁢ ileocecal region‍ (A, B, ⁢C, D)
⁢ * ⁤ Rectum (E,‍ F, G, ‍H)
⁤ * ‍Transverse colon (I)
* Descending ⁣colon (J)
* Sigmoid colon (K, L)
* M: H&E staining showing ‍an amebic trophozoite (indicated by a triangle in an orange frame).
* N: PAS staining showing positive staining for amebic organisms (purplish-red⁣ in an orange frame).

In essence, the ⁤text describes how pathologists identified the cause of the illness by looking at⁣ tissue samples under a microscope,⁤ using special stains to confirm the presence of the amebic ⁣parasite. The figure provides visual examples of what these findings look‍ like.