Amgen Five Prime: Gastric Cancer Deal
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pharmaphorum July 1, 2025
Four years after buying Five Prime for $1.9 billion, Amgen has promising phase 3 results with a drug for gastric cancer that was the focal point for the deal.
The new data comes from the FORTITUDE-101 looking at bemarituzumab plus chemotherapy as a front-line therapy for FGFR2b-positive advanced gastric cancer, and has revealed a significant improvement in overall survival (OS) compared to placebo plus chemo.
FGFR2b – fibroblast growth factor receptor 2b – is an emerging biomarker that is particularly prominent in gastric cancer and gastroesophageal junction (GEJ) cancer, occurring in around 38% of cases, and seems to promote the proliferation of tumour cells.
Bemarituzumab is directed against the receptor and is designed to inhibit the signalling pathways promoting tumour…
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2025-07-01T17:03:44-04:00