Andrée Marquet: Pioneering Chemist & Biology Innovator – A Tribute

The scientific community mourns the loss of Andrée Marquet, a pioneering French chemist who significantly advanced the field of organic biological chemistry. Professor Marquet, born in 1934, passed away recently, leaving behind a legacy of groundbreaking research, dedicated mentorship, and impactful leadership within the French scientific establishment.

Professor Marquet’s career began after completing her engineering studies at the École nationale supérieure de chimie de Paris and earning her doctorate at the Collège de France in 1961, followed by a postdoctoral fellowship at the ETH in Zurich. She subsequently joined the CNRS before being appointed Professor at the Pierre and Marie Curie University (now Sorbonne University) in 1978. It was at this institution that she founded the laboratory of organic biological chemistry, which evolved over the years into the UMR 7613, then the UMR 7203, and finally the UMR 8228 (Chemistry Physics and Chemistry of Living Things). This laboratory continues to thrive, carrying forward her vision through a community of researchers and educators passionate about the intersection of chemistry and biology.

Professor Marquet’s research focused on mechanistic enzymology, specifically investigating the biosynthesis of steroids, vitamin K, and biotin. Her work wasn’t solely confined to specific research themes; she was instrumental in shaping a new way of thinking within the field. She brought the principles of reactivity and mechanisms to biochemistry, bridging a gap that had previously existed, and firmly grounded organic chemistry in the complexities of living systems. She effectively created a common language for chemists and biochemists to communicate and collaborate.

Beyond her laboratory work, Professor Marquet was a committed advocate for the advancement of chemistry as a discipline. She held numerous scientific and institutional leadership positions, demonstrating a dedication to the broader scientific community. From 1984 to 1986, she chaired the organic chemistry division of the Société Chimique de France. She also led the Société Franco-japonaise de chimie fine et thérapeutique from 1987 to 1991. Her involvement extended to the CNRS, where she chaired section 20 of the National Committee (1991–1995) and served on the Scientific Council (1992–1997).

Professor Marquet’s influence reached into governmental spheres as well. In 1998, she became Scientific Director of the Chemistry Department at the Research Department of the MENRT (Ministry of National Education, Higher Education and Research). She served on the Board of Directors of the Palais de la Découverte from 1999 to 2003, and again on the Board of Directors of the MENRT from 2007 to 2008. In 2011, she became a member of the Ethics Committee of the CNRS.

Recognizing the importance of public engagement with science, Professor Marquet founded the “Chemistry and Society” Commission within the Fondation de la Maison de la Chimie in 2002, remaining its president until 2011. This commission aimed to foster dialogue and understanding between the scientific community and the broader public, highlighting the societal relevance of chemical research.

Professor Marquet was also a correspondent at the French Academy of sciences since 1993, a testament to the high regard in which her peers held her contributions. Her work, as noted in publications like “the changing image of the sciences,” inspired generations of colleagues and students. She was a true pioneer in the fields of bioorganic and biological chemistry.

The loss of Professor Marquet is deeply felt by the scientific community. Her dedication to research, education, and public service has left an indelible mark on the landscape of French science. Condolences are extended to her family and loved ones during this difficult time.