Antibiotic-Loaded Cement: Does It Reduce PJI Risk in Total Joint Arthroplasty?
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Study Findings:
Antibiotic-loaded cement vs. Plain Cement: A subanalysis of 20,000 patients showed that using antibiotic-loaded cement in primary total joint arthroplasty (THA and TKA) did not prevent periprosthetic joint infection (PJI) compared to using plain cement. Readmission Rates:
Cemented implants and implants with antibiotic-loaded cement had increased hazard ratios for readmission in Total Hip Arthroplasty (THA).
Implants with antibiotic-loaded cement had a higher hazard ratio for readmission in Total Knee Arthroplasty (TKA).
Cost Analysis:
Cost of Cement:
Antibiotic-loaded cement: $212 per patient
Plain cement: $67 per patient
Potential Savings: not using antibiotic-loaded cement could lead to cost savings of over $1.5 million.
Institutional Focus:
The researchers (led by Dr.Robilotti) aim to analyze their own institutional data to provide specific recommendations to surgeons based on their patient population.
Providing a concrete dollar value for potential cost savings is seen as vital when asking physicians to change practise.
Contact Information:
Elizabeth Robilotti, MD: mediarelations@hss.edu
Source:
Guerin K,et al. paper 1560. Presented at: Musculoskeletal Infection Society Annual Meeting; Aug.1-2, 2025; Jersey City, N.J.