Brain Mapping Consortium: Champalimaud Foundation Collaboration
- A groundbreaking study by the International Brain Laboratory (IBL), with significant contributions from the Champalimaud Foundation (FC), has revealed that decision-making isn't confined to specific brain regions but...
- For the first time, scientists were able to map decision-making as it occurs throughout the brain at the level of individual neurons.
- The Champalimaud Foundation played a crucial role in this advancement, not only through data collection but also through the growth of the infrastructure necessary to handle such a...
Whole-Brain Decision making: landmark Study Challenges Customary Neuroscience
Table of Contents
Published September 4, 2025, at 11:54:07 AM EDT
What Happened?
A groundbreaking study by the International Brain Laboratory (IBL), with significant contributions from the Champalimaud Foundation (FC), has revealed that decision-making isn’t confined to specific brain regions but involves the coordinated activity of the entire brain. Researchers recorded the activity of over half a million neurons across 279 brain areas during decision-making processes. The findings, published in Nature, challenge the long-held belief that decisions are processed hierarchically in specialized areas.
For the first time, scientists were able to map decision-making as it occurs throughout the brain at the level of individual neurons. Instead of localized processing, the study shows that signals are widely distributed, activating nearly the entire brain in a coordinated fashion. The Champalimaud Foundation’s system neuroscience laboratory was one of twelve experimental labs involved in the large-scale neural recordings.
The champalimaud Foundation’s Role
The Champalimaud Foundation played a crucial role in this advancement, not only through data collection but also through the growth of the infrastructure necessary to handle such a massive dataset. The Lisbon institution hosted much of the engineering team responsible for building this unprecedented data-gathering system. This highlights the Foundation’s commitment to cutting-edge neuroscience research and technological innovation.
Key Findings & Data
Zachary Mainen,a lead researcher at the Champalimaud Foundation and a founding member of the IBL,explained,”Traditionally,neuroscientists studied a brain region at a time.Here we raised the bar in a dramatic way.” The study’s key data points include:
- Neurons Recorded: Over 500,000
- Brain Areas Examined: 279
- Methodology: Large-scale neural recordings during decision-making tasks
- Publication: Nature (publication date to be confirmed)

Challenging the Hierarchical Model
The traditional view of decision-making posits a hierarchical process, where facts flows through specialized brain regions in a sequential manner. For example, sensory information might first be processed in the visual cortex, then passed to areas involved in planning, and finally to motor areas for execution. this study suggests a more distributed and integrated model, where many brain areas contribute simultaneously to the decision-making process.
