Chemostat Culturing: Reducing Eukaryotic Virus Load and Diarrhea Post-Virome Transplantation

Title: Chemostat Culturing Reduces Fecal Eukaryotic Virus Load and Delays Diarrhea After Virome Transplantation

Authors: Simone Margaard Offersen, Signe Adamberg, Malene Roed Spiegelhauer, Xiaotian Mao, Torben Solbeck Rasmussen, Frej Larsen, Jingren Zhong, Duc Ninh Nguyen, Dennis Sandris Nielsen, Lise Aunsholt, Thomas Thymann, Kaarel Adamberg, Anders Brunse

Journal: bioRxiv
Date: November 20, 2024
DOI: 10.1101/2024.11.20.624498

Summary:
This study investigates the effects of chemostat culturing on fecal eukaryotic virus load and diarrhea following virome transplantation. Chemostat culturing significantly reduced the viral load in fecal samples. It also delayed the onset of diarrhea, suggesting a potential strategy for improving outcomes in virome transplantation. The findings indicate that controlling the microbial environment through chemostat culturing can be beneficial for gastrointestinal health.