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Logo Berliner Morgenpost

Christina Applegate Reveals Five-Year Multiple Sclerosis Misdiagnosis

October 22, 2026 Marcus Rodriguez Entertainment
News Context
At a glance
  • Christina Applegate learned that she does not have multiple sclerosis after five years of medical treatment for the condition, morgenpost.de reported.
  • Applegate revealed that her original 2021 diagnosis of multiple sclerosis provided a long-sought explanation for severe physical symptoms that eventually required her to use a wheelchair.
  • The correction brought no relief to the actor, who stated she was not happy because her severe health issues persist without a valid diagnosis, morgenpost.de noted.
Original source: morgenpost.de

Christina Applegate learned that she does not have multiple sclerosis after five years of medical treatment for the condition, morgenpost.de reported. The 54-year-old actor shared the news on her podcast, MeSsy, explaining that a doctor recently reevaluated her condition and told her she was misdiagnosed.

The Misdiagnosis Revelation on MeSsy

Applegate revealed that her original 2021 diagnosis of multiple sclerosis provided a long-sought explanation for severe physical symptoms that eventually required her to use a wheelchair. Multiple sclerosis is a chronic inflammatory and currently incurable disease of the central nervous system that can cause pain, paralysis, and severe exhaustion, among other things. She stated that she had always experienced all the symptoms of the disease. However, after undergoing harsh treatments including heavy body infusions that failed to produce expected changes, a physician reexamined her medical history, according to rtl.de. The doctor ultimately informed her, Herzlichen Glückwunsch, Sie haben keine MS, as reported by morgenpost.de. Multiple sclerosis is repeatedly subject to misdiagnoses because the condition cannot be clearly proven by a single test; instead, doctors rely on various examinations and must rule out other possible causes for the symptoms.

The Ongoing Health Struggles Without Answers

The correction brought no relief to the actor, who stated she was not happy because her severe health issues persist without a valid diagnosis, morgenpost.de noted. Applegate described herself as being back at the very beginning of her medical journey, noting that her condition in some ways feels worse now that the underlying cause remains completely unknown, according to rtl.de.

Broader Context of Hollywood Medical Misdiagnoses

Applegate joins several other public figures who have experienced significant medical misdiagnoses, rtl.de reported. Lucy Liu underwent an unnecessary breast surgery in 1991 at age 22 after a doctor incorrectly classified a lump as cancer through manual palpation alone without a mammogram or ultrasound, an experience that taught her to question medical assessments more strongly. Kylie Minogue received an initial all-clear in 2005 before a breast cancer diagnosis was properly confirmed weeks later, a mistake she made public in Ellen DeGeneres’ talk show in 2008 to convey that doctors can also be wrong. Country musician Kris Kristofferson spent years treated for Alzheimer’s disease and dementia while battling increasing memory problems before doctors diagnosed him with Lyme disease in 2016, after which his condition improved significantly following appropriate treatment, as his wife Lisa reported to the Huffington Post and other outlets at the time. Halle Berry experienced severe intimate area pain that a gynecologist initially misdiagnosed as an advanced case of herpes before tests for both Berry and her partner Van Hunt proved negative and her symptoms were actually linked to the perimenopause, the hormonal transitional phase before menopause, as she explained on The Drew Barrymore Show. Actor Olivia Williams spent four years seeking answers for symptoms while doctors suspected conditions including lupus, irritable bowel syndrome, or menopause symptoms until a rare neuroendocrine condition was identified in 2018, according to rtl.de reporting.

More on Multiple Sclerosis: NAC Treatment Alters Brain Connectivity and Metabolism in Multiple Sclerosis

Christina Applegate Reveals Five-Year Multiple Sclerosis Misdiagnosis
Photo: rtl.de

Ich bin wieder ganz am Anfang.

rtl.de

Christina Applegate says she was misdiagnosed with multiple sclerosis

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