Clascoterone Cream for Facial Oil & Acne Reduction
Summary of Research on Clascoterone for Acne
This article reports on a year-long study investigating the long-term effects of clascoterone cream (1%) on individuals with mild to moderate acne. Hear’s a breakdown of the key findings:
Key Findings:
* Important Sebum Reduction: After 52 weeks of twice-daily submission, participants experienced a 47% reduction in sebum levels (from a mean of 115.9 to 61.5, P < .001). This confirms clascoterone’s long-term sebum-reducing ability.
* Acne Lesion Enhancement: The study also showed considerable improvements in acne itself:
* 73% decrease in inflammatory lesions (P < .001)
* 61% decrease in non-inflammatory lesions (P <.001)
* 55% reduction in Investigator Global Assessment (IGA) score (P < .001)
* Good Tolerability: The treatment was well-tolerated, with no significant changes in reported tolerability. one participant experienced mycoplasma pneumonia, but it was resolved with antibiotics and deemed unrelated to the clascoterone.
* Ongoing Research: Researchers are currently analyzing sebum composition to see if clascoterone alters it,using liquid chromatography/mass spectrometry (LC-MS).
Study Details:
* Participants: 40 individuals with mild (57.5%) or moderate acne (42.5%). Mean age 20.9 years,60% female,62.5% white.
* Methodology: Single-site, exploratory study.Participants applied clascoterone twice daily for 52 weeks. sebum measurements, facial characteristics assessments, lesion counts, and patient self-assessments of side effects were taken.
* Source: Presented at the Fall Clinical Dermatology Conference, October 23-26, 2025, Las Vegas.
Researcher:
* Zoe Diana Draelos, MD (dcs@northstate.net) – reports receiving grant funding from sun Pharmaceuticals.
In essence,the study provides strong evidence that clascoterone is an effective long-term treatment for acne,primarily through its ability to reduce sebum production.