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COVID-19 Genetic Risk Across Populations

October 25, 2025 Dr. Jennifer Chen Health

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Citation List

* 23. O’Driscoll M, Ribeiro Dos Santos⁢ G, Wang‍ L, ⁤et‍ al. Age-specific mortality‌ and immunity patterns of SARS-CoV-2.Nature. 2021;590(7844):140-145. doi:10.1038/s41586-020-2918-0
* ‍ 24. Raza RZ, ⁢Abbasi SW. An evolutionary insight into the heterogeneous severity pattern of the SARS-CoV-2 infection.‌ Front Genet. 2022;13:859508. doi:10.3389/fgene.2022.859508
* ‌ ⁢ 25. ⁤Alharbi AM, Rabbani SI, Halim⁢ Mohamed AA, et al. Analysis⁣ of potential risk factors associated with COVID-19 and hospitalization. Front Public⁤ Health. 2022;10:921953. doi:10.3389/fpubh.2022.921953
* 26. Degenhardt F, Ellinghaus D, Juzenas S, et ‌al.⁢ Detailed stratified GWAS analysis‌ for severe COVID-19 in ⁢four European populations.Hum Mol⁤ Genet. 2022.⁣ doi:10.1093/hmg/ddac158
* ​ 27. ⁢Severe Covid GG, ⁢Ellinghaus D, Degenhardt‌ F, et al. Genomewide association study of severe Covid-19 with respiratory failure. N Engl J Med. 2020;383(16):1522-1534. doi:10.1056/NEJMoa2020283
* 28. Shelton JF, Shastri⁢ AJ, Ye C, et al. Trans-ancestry analysis reveals genetic and nongenetic⁣ associations with COVID-19 susceptibility and severity. Nat Genet. 2021;53(6):801-808. doi:10.1038/s41588-021-00854-7
* 29. Horowitz JE, Kosmicki ⁣JA, Damask​ A, ⁢et al. Genome-wide analysis provides genetic evidence that⁣ ACE2 influences COVID-19 risk and yields risk ‍scores⁣ associated with severe⁤ disease.Nat Genet. 2022;54(4):382-392. doi:10.1038/s41588-021-01006-7
* 30. Pairo-Castineira E, Clohisey S, klaric L, et al. Genetic mechanisms of critical illness in COVID-19. Nature. 2021;591(7848):92-98.⁢ doi:10.1038/s41586-020-03065-y
* 31. Boettger LM, Handsaker RE, ⁣Zody MC, McCarroll SA. Structural​ haplotypes and recent evolution of the human ‍17q21.31⁤ region. Nat Genet. 2012;44(8):881-885.doi:10.1038/ng.2334
* ‌ 32. Stefansson H, Helgason A, ⁣Thorleifsson G, et al.A common inversion under selection in Europeans.Nat Genet. 2005;37(2):129-137. doi:10.1038/ng1508
* ⁣ 33. Li S, Wang Y, Zhang ‌Y, et al. Foxp1/4 control epithelial cell ‍fate durin

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