Devil Wears Prada 2 Trailer: Ozempic Jokes & First Reactions

The upcoming sequel to the 2006 film The Devil Wears Prada is already generating discussion, and not solely for its return to the world of high fashion. Initial reactions to the trailer, released this week, suggest the film may address contemporary cultural conversations surrounding weight-loss medications, specifically Ozempic.

A Return to the Runway and Relevant Cultural Commentary

The film, slated for release in theaters on May 1, 2026, brings back the original cast including Meryl Streep as Miranda Priestly, Anne Hathaway as Andy Sachs, Emily Blunt as Emily Charlton, and Stanley Tucci as Nigel Kipling. The trailer depicts a reunion between Sachs and Priestly, with a brief exchange hinting at Sachs’s evolved confidence. The trailer also shows glimpses of the characters at the Met Gala.

However, it’s a prediction from a New York Times style reporter that has sparked particular interest. Following the trailer’s release, the reporter posited that the film will include at least one joke referencing Ozempic. This observation suggests the filmmakers are acknowledging, and potentially satirizing, the growing cultural impact of these medications.

Ozempic and the Broader Context of Weight Management

Ozempic (semaglutide) is a medication originally developed to treat type 2 diabetes. It belongs to a class of drugs called glucagon-like peptide-1 (GLP-1) receptor agonists. These medications work by mimicking the effects of GLP-1, a natural hormone that helps regulate blood sugar levels. GLP-1 agonists can also promote weight loss by slowing gastric emptying, increasing feelings of fullness, and reducing appetite.

While initially prescribed for diabetes management, Ozempic and similar drugs (like Wegovy, which contains a higher dose of semaglutide and is specifically approved for weight loss) have gained significant attention for their off-label use as weight-loss aids. This has led to both increased demand and, supply shortages for individuals who rely on these medications for their intended purpose – managing diabetes.

Cultural Impact and Potential for Satire

The predicted inclusion of an Ozempic reference in The Devil Wears Prada 2 speaks to the drug’s permeation into mainstream culture. The fashion industry, known for its often-unrealistic beauty standards, is particularly relevant to this conversation. The original The Devil Wears Prada explored the pressures and sacrifices associated with achieving a certain aesthetic within that world. A sequel addressing the use of weight-loss medications could offer a commentary on the evolving, and potentially problematic, methods employed to meet those standards.

Emily Blunt, reprising her role as Emily Charlton, noted that stepping back into the character felt remarkably easy, describing her as a “lunatic.” This suggests the sequel will retain the sharp, satirical edge of the original, potentially extending that critique to contemporary trends in weight management.

Navigating the Complexities of GLP-1 Agonists

It’s important to note that GLP-1 agonists are not without potential side effects. Common side effects include nausea, vomiting, diarrhea, and constipation. More serious, though less common, side effects have also been reported. Individuals considering these medications should engage in a thorough discussion with their healthcare provider to assess the risks and benefits, and to determine if they are appropriate candidates.

The film’s potential engagement with this topic could raise awareness about the complexities surrounding these medications, prompting viewers to consider the ethical and societal implications of their use. The trailer shows a dynamic between Andy and Emily, with Emily noting Andy’s increased confidence, but also a continued adherence to a specific aesthetic (“You kept those eyebrows, though, didn’t you?”). This exchange could be interpreted as a subtle nod to the ongoing pressures to conform to beauty ideals, even with evolving approaches to weight management.

Looking Ahead

As today, February 3, 2026, the full extent of the film’s commentary on Ozempic and related issues remains to be seen. However, the initial reactions to the trailer suggest The Devil Wears Prada 2 may offer a timely and thought-provoking exploration of contemporary cultural trends, blending the glamour of the fashion world with a critical lens on societal pressures and the evolving landscape of weight management.