Echovirus 18 Meningitis Niger – Case Report 2024

Okay, here’s a⁢ breakdown of the key details from the provided text, focusing ‍on the patient’s case ⁤and ⁢the diagnostic process:

Patient Presentation⁢ & ⁣Initial Course:

* Symptoms: The patient presented with fever,⁣ headache, vomiting, and general malaise.
* Lab findings (Initial): Low white⁣ blood cell⁤ count (<5/mm³) and high ⁢red blood cell count (1250/mm³). Bacterial meningitis ⁢was initially considered but ruled out.
* Deterioration: The patient’s condition worsened, developing epistaxis (nosebleeds), persistently ‍high fever (39-40°C), and convulsions.
* ⁢ ‍ Outcome: The patient died after two days of treatment on November 21st, 2024.

Diagnostic Inquiry:

*⁢ ⁣‍ Hemorrhagic Fever Screening: ⁣ Due to the ⁣appearance of⁤ hemorrhagic ⁣signs, the patient’s blood was tested for a range of hemorrhagic fever viruses (Dengue, Rift Valley Fever, Yellow Fever, Chikungunya, West nile, Zika, Crimean-Congo, Lassa, Ebola/Marburg). All tests were ⁣negative.

* Advanced Sequencing (Institut Pasteur de ⁢Dakar): A serum⁢ sample underwent genomic sequencing using an enrichment library planning⁢ method and Illumina Iseq100 instrument. Data was analyzed using ⁣the⁢ Chan Zuckerberg ID platform. Phylogenetic analysis was performed using IQ-TREE. Recombination analysis was performed using Simplot and RDP5.

Key Finding:

*⁤ Echovirus 18 Identification: genomic sequencing confirmed the presence of Echovirus 18 with 95% genome coverage. The virus belonged ⁢to genotype B.

In essence, the patient died from ⁣an infection with Echovirus 18, which was only identified thru advanced genomic sequencing after initial tests for ⁤more common and hazardous pathogens were negative.